MAP3K2
mitogen-activated protein kinase kinase kinase 2
Summary
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Known Variants22 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4233583 | 2:128,060,068 | C/A | 3 prime UTR variant | — |
| rs774242849 | 2:128,065,196 | C/T | — | uncertain significance |
| rs373484478 | 2:128,065,250 | A/G | — | uncertain significance |
| rs367985321 | 2:128,066,165 | T/C | — | uncertain significance |
| rs2468107875 | 2:128,066,241 | C/G | — | uncertain significance |
| rs2468107954 | 2:128,066,260 | C/G | — | uncertain significance |
| rs778700907 | 2:128,066,336 | C/T | — | uncertain significance |
| rs749846597 | 2:128,072,459 | C/T | — | uncertain significance |
| rs766276577 | 2:128,075,224 | A/T | — | uncertain significance |
| rs200753745 | 2:128,075,265 | A/G | — | benign |
| rs373223980 | 2:128,075,765 | C/T | — | uncertain significance |
| rs765352195 | 2:128,075,816 | C/T | — | uncertain significance |
| rs750916978 | 2:128,075,827 | T/C | — | uncertain significance |
| rs79135681 | 2:128,079,788 | G/T | — | benign |
| rs2468137962 | 2:128,079,810 | C/A | — | uncertain significance |
| rs200531096 | 2:128,084,303 | A/T | — | uncertain significance |
| rs776705567 | 2:128,087,575 | A/T | — | uncertain significance |
| rs2468157208 | 2:128,087,988 | C/A | — | uncertain significance |
| rs766702550 | 2:128,088,005 | C/T | — | uncertain significance |
| rs371455925 | 2:128,095,348 | C/T | — | uncertain significance |
| rs545987655 | 2:128,097,127 | T/C | — | — |
| rs55998444 | 2:128,119,846 | T/C | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.