MAPK4
mitogen-activated protein kinase 4
Summary
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Known Variants43 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs61148001 | 18:48,133,241 | C/T | intron variant | — |
| rs12954097 | 18:48,135,618 | G/C | — | — |
| rs58000211 | 18:48,138,375 | A/C | — | — |
| rs58693787 | 18:48,141,710 | A/G | intron variant | — |
| rs745821 | 18:48,142,854 | T/G | intron variant | — |
| rs1025685 | 18:48,147,122 | A/T | intron variant | — |
| rs1025686 | 18:48,147,127 | A/T | — | — |
| rs8089368 | 18:48,154,454 | A/G | regulatory region variant | — |
| rs772545058 | 18:48,190,350 | A/G | — | uncertain significance |
| rs374524649 | 18:48,190,377 | G/A | — | uncertain significance |
| rs34207571 | 18:48,190,378 | G/A | — | uncertain significance |
| rs776211637 | 18:48,190,449 | C/T | — | uncertain significance |
| rs55800528 | 18:48,190,511 | C/T | — | likely benign |
| rs1360934897 | 18:48,190,553 | C/A | — | uncertain significance |
| rs200812352 | 18:48,190,659 | G/A | — | uncertain significance |
| rs775778917 | 18:48,190,716 | A/G | — | uncertain significance |
| rs376363938 | 18:48,190,815 | G/C | — | uncertain significance |
| rs761132815 | 18:48,190,851 | G/A | — | uncertain significance |
| rs368403152 | 18:48,241,538 | G/A | — | uncertain significance |
| rs77677063 | 18:48,248,304 | C/T | — | likely benign |
| rs751114736 | 18:48,248,315 | T/A | — | uncertain significance |
| rs2511483902 | 18:48,248,318 | G/A | — | likely benign |
| rs267605202 | 18:48,248,379 | G/A | — | uncertain significance |
| rs1910964961 | 18:48,248,432 | G/C | — | uncertain significance |
| rs2511484542 | 18:48,248,462 | C/A | — | uncertain significance |
| rs183692158 | 18:48,252,428 | G/A | — | uncertain significance |
| rs753210882 | 18:48,252,463 | C/T | — | uncertain significance |
| rs199859025 | 18:48,252,498 | G/A | — | uncertain significance |
| rs368928539 | 18:48,252,524 | A/G | — | uncertain significance |
| rs3752089 | 18:48,255,572 | G/A | — | uncertain significance |
| rs747597763 | 18:48,255,767 | C/T | — | uncertain significance |
| rs751431559 | 18:48,255,815 | C/T | — | uncertain significance |
| rs1911417335 | 18:48,255,887 | T/C | — | uncertain significance |
| rs1030394148 | 18:48,255,896 | C/G | — | uncertain significance |
| rs1216233572 | 18:48,255,938 | T/C | — | uncertain significance |
| rs1372606225 | 18:48,255,983 | G/C | — | uncertain significance |
| rs989851014 | 18:48,255,986 | C/A | — | uncertain significance |
| rs1377257004 | 18:48,255,994 | G/A | — | uncertain significance |
| rs555824518 | 18:48,256,022 | C/T | — | uncertain significance |
| rs766321769 | 18:48,256,024 | C/G | — | uncertain significance |
| rs758675898 | 18:48,256,030 | G/A | — | uncertain significance |
| rs757385194 | 18:48,256,043 | C/G | — | uncertain significance |
| rs1911441689 | 18:48,256,062 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.