MARCO
macrophage receptor with collagenous structure
Summary
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
Known Variants49 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2467020673 | 2:119,699,895 | C/A | — | uncertain significance |
| rs766145276 | 2:119,699,901 | G/A | — | uncertain significance |
| rs80217020 | 2:119,699,906 | C/T | — | likely benign |
| rs775618424 | 2:119,699,971 | A/G | — | likely benign |
| rs111563275 | 2:119,703,232 | G/A | downstream gene variant | — |
| rs980715 | 2:119,717,726 | A/G | intron variant | — |
| rs12998782 | 2:119,725,380 | C/T | intron variant | — |
| rs17009726 | 2:119,725,460 | A/G | intron variant | — |
| rs1392081299 | 2:119,726,752 | G/T | — | uncertain significance |
| rs374405181 | 2:119,726,780 | G/A | — | uncertain significance |
| rs779729953 | 2:119,726,810 | G/A | — | uncertain significance |
| rs144080988 | 2:119,727,692 | C/G | — | uncertain significance |
| rs769113753 | 2:119,727,750 | C/T | — | uncertain significance |
| rs1456356736 | 2:119,727,818 | G/A | — | uncertain significance |
| rs760316668 | 2:119,727,854 | T/C | — | uncertain significance |
| rs757193219 | 2:119,727,907 | G/A | — | likely benign |
| rs2467080591 | 2:119,729,075 | G/A | — | likely benign |
| rs535379325 | 2:119,729,104 | G/A | — | uncertain significance |
| rs17795618 | 2:119,731,468 | T/C | — | — |
| rs2467087793 | 2:119,731,912 | T/A | — | uncertain significance |
| rs1185170201 | 2:119,731,940 | G/A | — | uncertain significance |
| rs2467087961 | 2:119,731,943 | T/A | — | likely benign |
| rs140806715 | 2:119,731,957 | C/G | — | uncertain significance |
| rs150463190 | 2:119,731,960 | C/T | — | uncertain significance |
| rs758848121 | 2:119,732,002 | G/A | — | uncertain significance |
| rs778750279 | 2:119,732,136 | A/T | — | uncertain significance |
| rs1371562 | 2:119,732,948 | G/C | — | — |
| rs769029216 | 2:119,735,491 | A/G | — | uncertain significance |
| rs756644380 | 2:119,739,047 | G/A | — | uncertain significance |
| rs2467103720 | 2:119,739,061 | C/A | — | uncertain significance |
| rs6761637 | 2:119,739,063 | T/C | missense variant | — |
| rs554611818 | 2:119,739,747 | A/C | — | uncertain significance |
| rs147872741 | 2:119,739,754 | T/C | — | benign |
| rs369805550 | 2:119,739,756 | C/T | — | uncertain significance |
| rs1221791454 | 2:119,739,764 | C/T | — | uncertain significance |
| rs142540932 | 2:119,739,783 | C/G | — | uncertain significance |
| rs932313923 | 2:119,739,822 | G/A | — | uncertain significance |
| rs752659536 | 2:119,739,949 | A/T | — | likely benign |
| rs201332622 | 2:119,739,972 | G/A | — | uncertain significance |
| rs2011839 | 2:119,742,584 | C/A | — | — |
| rs78198921 | 2:119,749,146 | C/G | intron variant | — |
| rs2467128278 | 2:119,749,416 | G/A | — | uncertain significance |
| rs140986899 | 2:119,749,442 | G/A | — | uncertain significance |
| rs2467128357 | 2:119,749,443 | G/T | — | uncertain significance |
| rs765014059 | 2:119,750,742 | G/A | — | uncertain significance |
| rs770063533 | 2:119,750,795 | G/A | — | uncertain significance |
| rs371994323 | 2:119,751,999 | G/A | — | likely benign |
| rs201104770 | 2:119,752,029 | C/T | — | uncertain significance |
| rs534643409 | 2:119,752,218 | A/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.