MDGA1
MAM domain containing glycosylphosphatidylinositol anchor 1
Summary
This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016]
Known Variants74 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs111244846 | 6:37,599,995 | C/T | downstream gene variant | — |
| rs41273092 | 6:37,605,010 | G/A | — | — |
| rs184891828 | 6:37,605,157 | G/A | — | uncertain significance |
| rs766003255 | 6:37,605,211 | G/A | — | uncertain significance |
| rs764414730 | 6:37,605,223 | G/A | — | uncertain significance |
| rs780711872 | 6:37,605,997 | C/A | — | uncertain significance |
| rs201447768 | 6:37,606,004 | C/T | — | uncertain significance |
| rs74703632 | 6:37,606,036 | A/G | — | benign |
| rs201158201 | 6:37,606,063 | C/A | — | benign |
| rs371103978 | 6:37,606,064 | G/A | — | uncertain significance |
| rs864309493 | 6:37,606,083 | A/C | — | uncertain significance |
| rs201772848 | 6:37,606,331 | G/A | — | likely benign |
| rs1291225878 | 6:37,606,440 | G/A | — | uncertain significance |
| rs780576411 | 6:37,611,617 | G/A | — | uncertain significance |
| rs1207973587 | 6:37,611,641 | G/T | — | uncertain significance |
| rs1320578407 | 6:37,611,651 | G/C | — | uncertain significance |
| rs760488481 | 6:37,611,653 | G/A | — | uncertain significance |
| rs370910887 | 6:37,611,672 | G/A | — | uncertain significance |
| rs763798669 | 6:37,611,681 | G/T | — | uncertain significance |
| rs1426606313 | 6:37,611,714 | A/G | — | uncertain significance |
| rs864309630 | 6:37,612,339 | G/A | — | uncertain significance |
| rs772803184 | 6:37,612,425 | T/C | — | uncertain significance |
| rs199598893 | 6:37,613,995 | G/A | — | uncertain significance |
| rs766878885 | 6:37,614,004 | T/C | — | uncertain significance |
| rs192113659 | 6:37,614,044 | C/G | — | benign |
| rs200578177 | 6:37,614,125 | C/A | — | uncertain significance |
| rs193129932 | 6:37,616,033 | G/T | regulatory region variant | — |
| rs535046433 | 6:37,616,328 | C/T | — | — |
| rs1005643073 | 6:37,616,808 | C/A | — | uncertain significance |
| rs142960358 | 6:37,616,846 | G/C | synonymous variant | — |
| rs774032650 | 6:37,616,866 | C/T | — | uncertain significance |
| rs950618708 | 6:37,616,907 | A/G | — | uncertain significance |
| rs560734390 | 6:37,616,937 | G/A | — | uncertain significance |
| rs938882933 | 6:37,616,992 | G/A | — | uncertain significance |
| rs913385156 | 6:37,617,010 | C/T | — | uncertain significance |
| rs374088920 | 6:37,617,018 | G/A | — | uncertain significance |
| rs804815 | 6:37,617,892 | G/A | — | benign |
| rs764209266 | 6:37,617,941 | C/T | — | uncertain significance |
| rs528612629 | 6:37,617,979 | G/T | — | uncertain significance |
| rs1761333434 | 6:37,618,176 | G/A | — | uncertain significance |
| rs116192533 | 6:37,618,820 | A/T | intron variant | — |
| rs199847584 | 6:37,619,815 | G/C | — | uncertain significance |
| rs1243452471 | 6:37,619,823 | C/A | — | uncertain significance |
| rs1250345189 | 6:37,619,837 | C/T | — | uncertain significance |
| rs564044265 | 6:37,619,952 | G/A | — | uncertain significance |
| rs9462343 | 6:37,620,776 | G/A | intron variant | — |
| rs758681977 | 6:37,622,256 | G/A | — | uncertain significance |
| rs1174891037 | 6:37,622,274 | T/C | — | uncertain significance |
| rs369840766 | 6:37,622,621 | C/T | — | uncertain significance |
| rs370124284 | 6:37,623,480 | G/A | — | uncertain significance |
| rs779605580 | 6:37,623,519 | C/T | — | uncertain significance |
| rs747208401 | 6:37,623,543 | C/T | — | uncertain significance |
| rs2481978873 | 6:37,623,544 | G/A | — | uncertain significance |
| rs765133851 | 6:37,623,564 | G/A | — | uncertain significance |
| rs2481993448 | 6:37,626,110 | A/G | — | uncertain significance |
| rs1240462031 | 6:37,626,162 | C/A | — | uncertain significance |
| rs10807187 | 6:37,629,650 | G/A | — | — |
| rs13203140 | 6:37,630,133 | C/T | intron variant | — |
| rs1883901 | 6:37,631,031 | G/A | intron variant | — |
| rs544453423 | 6:37,631,799 | G/A | — | uncertain significance |
| rs772366869 | 6:37,631,814 | G/A | — | uncertain significance |
| rs2482020636 | 6:37,631,815 | C/T | — | likely benign |
| rs199995727 | 6:37,631,846 | G/A | — | uncertain significance |
| rs755556368 | 6:37,631,862 | C/T | — | uncertain significance |
| rs72847482 | 6:37,635,881 | G/T | intron variant | — |
| rs141938252 | 6:37,636,220 | A/G | regulatory region variant | — |
| rs7769372 | 6:37,638,562 | C/T | intron variant | — |
| rs11759115 | 6:37,641,030 | T/C | intron variant | — |
| rs181316709 | 6:37,643,791 | G/C | intron variant | — |
| rs144381013 | 6:37,649,564 | G/A | intron variant | — |
| rs557835320 | 6:37,650,874 | T/C | — | — |
| rs576458215 | 6:37,651,584 | A/G | — | — |
| rs187214315 | 6:37,654,973 | G/A | intron variant | — |
| rs559178785 | 6:37,664,577 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.