MEG3

maternally expressed 3

Summary

This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]

Known Variants47 total

rsidPosition (GRCh37)AllelesClassClinVar
rs4549709714:101,295,729G/A—likely benign
rs94157514:101,295,830C/G—benign
rs4557053214:101,297,367G/T—likely benign
rs103250653114:101,297,392G/A—likely benign
rs308791814:101,297,963T/Gregulatory region variant—
rs7269876314:101,298,291G/T—benign
rs93426386414:101,300,968G/T—uncertain significance
rs52986116214:101,301,341G/A—benign
rs250378760414:101,301,849T/C—uncertain significance
rs19201026214:101,302,041G/A—likely benign
rs14126257614:101,302,372C/A—likely benign
rs13821939514:101,302,607G/A—likely benign
rs14370036414:101,302,619G/A—likely benign
rs94157614:101,306,045A/Gintron variant—
rs6199330914:101,310,162C/Tregulatory region variant—
rs15119124914:101,311,788G/C—benign
rs54615462514:101,312,413G/A—likely benign
rs14903497414:101,312,653C/T—likely benign
rs1116060814:101,313,093A/T——
rs14469797214:101,314,582G/A—likely benign
rs18634547914:101,315,157C/T—likely benign
rs715542814:101,315,163G/A—benign
rs490047814:101,315,481A/C—benign
rs55931657914:101,315,581A/G—likely benign
rs490602314:101,315,668A/G—benign
rs18214338314:101,315,770A/G—benign
rs14030511814:101,315,821G/A—likely benign
rs18319765614:101,316,384A/T—likely benign
rs18851160714:101,316,392C/T—likely benign
rs53858359014:101,317,582C/T—likely benign
rs14725265014:101,317,659G/T—likely benign
rs378335714:101,317,791G/A—benign
rs229538914:101,318,311C/G—benign
rs14993621314:101,318,324T/G—benign
rs7855595414:101,318,358G/A—benign
rs11339973014:101,318,837A/G—benign
rs11596751014:101,319,068C/T—benign
rs11787704114:101,319,086T/C—benign
rs715866314:101,319,424A/Gdownstream gene variantbenign
rs14342461414:101,320,101A/G—likely benign
rs18127843914:101,322,403C/T—benign
rs11152370614:101,324,591G/A—benign
rs1162420714:101,324,644C/T—likely benign
rs11565186014:101,325,225T/Cintron variant—
rs4556064414:101,325,525G/C—benign
rs14267704414:101,327,083G/C—benign
rs5810270914:101,327,317G/A—benign

Gene information from NCBI Gene. Variant classifications from ClinVar.