MICB
MHC class I polypeptide-related sequence B
Summary
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Known Variants63 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12195665 | 6:31,461,043 | G/A | downstream gene variant | — |
| rs2507971 | 6:31,461,372 | A/T | downstream gene variant | — |
| rs9267325 | 6:31,461,492 | G/C | regulatory region variant | — |
| rs569668387 | 6:31,461,976 | C/T | — | — |
| rs3130923 | 6:31,462,135 | G/A | regulatory region variant | — |
| rs2516411 | 6:31,462,324 | C/A | regulatory region variant | — |
| rs2534681 | 6:31,462,931 | T/A | regulatory region variant | — |
| rs2516409 | 6:31,463,408 | T/G | regulatory region variant | — |
| rs6916394 | 6:31,464,050 | T/C | downstream gene variant | — |
| rs3828903 | 6:31,464,739 | G/A | upstream gene variant | — |
| rs778067972 | 6:31,465,981 | G/A | — | uncertain significance |
| rs764811801 | 6:31,466,035 | C/A | — | uncertain significance |
| rs752426500 | 6:31,466,036 | C/T | — | benign |
| rs3828919 | 6:31,466,057 | G/A | regulatory region variant | — |
| rs41293864 | 6:31,466,217 | C/T | regulatory region variant | — |
| rs9267374 | 6:31,466,287 | T/C | regulatory region variant | — |
| rs9267375 | 6:31,466,294 | T/C | — | — |
| rs41293876 | 6:31,466,536 | G/T | — | — |
| rs2855804 | 6:31,467,365 | C/T | upstream gene variant | — |
| rs558629389 | 6:31,467,527 | C/T | — | — |
| rs9378160 | 6:31,467,992 | A/T | — | — |
| rs2534664 | 6:31,469,591 | G/T | — | — |
| rs3095233 | 6:31,469,774 | A/T | — | — |
| rs3095232 | 6:31,470,148 | G/A | intron variant | — |
| rs189176068 | 6:31,470,944 | G/A | intron variant | — |
| rs9267416 | 6:31,472,019 | C/G | intron variant | — |
| rs2855812 | 6:31,472,720 | G/T | intron variant | — |
| rs28703977 | 6:31,472,792 | T/G | — | — |
| rs2507967 | 6:31,472,956 | G/A | — | — |
| rs191346397 | 6:31,472,990 | C/T | intron variant | — |
| rs2481186259 | 6:31,473,430 | C/T | — | uncertain significance |
| rs201389364 | 6:31,473,462 | G/A | — | uncertain significance |
| rs1216258695 | 6:31,473,496 | G/A | — | likely benign |
| rs373681038 | 6:31,473,514 | G/A | — | uncertain significance |
| rs755329733 | 6:31,473,573 | A/G | — | uncertain significance |
| rs778578532 | 6:31,473,582 | G/A | — | uncertain significance |
| rs2150289789 | 6:31,473,600 | G/A | — | uncertain significance |
| rs3130616 | 6:31,473,746 | G/A | intron variant | — |
| rs530797467 | 6:31,473,920 | G/A | — | uncertain significance |
| rs3134900 | 6:31,473,957 | C/G | missense variant | — |
| rs1383911821 | 6:31,473,985 | C/T | — | likely benign |
| rs200513000 | 6:31,474,043 | C/T | — | uncertain significance |
| rs775923426 | 6:31,474,087 | G/A | — | likely benign |
| rs751253633 | 6:31,474,130 | A/G | — | uncertain significance |
| rs752885996 | 6:31,474,136 | G/A | — | uncertain significance |
| rs1765331429 | 6:31,474,189 | G/T | — | uncertain significance |
| rs192400273 | 6:31,474,507 | G/A | intron variant | — |
| rs754399495 | 6:31,474,852 | G/A | — | uncertain significance |
| rs760425014 | 6:31,474,903 | C/T | — | uncertain significance |
| rs1385051923 | 6:31,474,976 | A/G | — | uncertain significance |
| rs1765396717 | 6:31,474,998 | G/C | — | uncertain significance |
| rs750745803 | 6:31,475,011 | G/A | — | uncertain significance |
| rs41273040 | 6:31,475,056 | G/A | missense variant | — |
| rs3131638 | 6:31,475,127 | A/T | — | — |
| rs781134713 | 6:31,475,196 | G/C | — | uncertain significance |
| rs368616699 | 6:31,475,203 | C/T | — | likely benign |
| rs3130615 | 6:31,475,413 | G/T | — | — |
| rs3132468 | 6:31,475,486 | C/G | — | — |
| rs9267426 | 6:31,476,363 | G/A | intron variant | — |
| rs3132464 | 6:31,477,461 | C/G | — | — |
| rs374022693 | 6:31,477,595 | T/C | — | uncertain significance |
| rs142597879 | 6:31,477,668 | T/C | — | benign |
| rs113617605 | 6:31,478,752 | G/C | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.