rs2855812

This is a intron variant variant in the MICB gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood protein amount

Emilsson V et al. “Co-regulatory networks of human serum proteins link genetics to disease.” Science (new York, N.y.) 361(6404):769-773 (2018)

Allele G

OR 0.70

p 2.0e-126

N 3,200

Large GWAS

European

asthma

Demenais F et al. “Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.” Nature Genetics 50(1):42-53 (2018)

Allele T

OR 1.10

p 9.0e-12

N 142,486

Large GWAS

multi-ancestry

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Research that mentions this SNP (1)

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Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases

AssociationN=3,094Howson JM et al.(2012)· Diabetologia

This genome-wide association study identifies genetic loci associated with zinc transporter 8 autoantibodies (ZnT8A) positivity in 2,239 type 1 diabetes cases. The FCRL3 locus on chromosome 1 (rs7522061 T>C, p=1.13×10⁻¹⁶, OR=1.82) and HLA class I region (rs9258750 A>G, p=2.06×10⁻⁹) show strong associations with ZnT8A. The SLC30A8 rs13266634 (R325W) shows epitope-specific associations: strong association with ZnT8WA (p=9.26×10⁻²⁷) and negative association with ZnT8RA (p=7.20×10⁻¹⁷). Notably, these ZnT8A-associated loci do not alter type 1 diabetes risk, indicating ZnT8A is a downstream biomarker rather than primary pathogenic factor.

Traits studied:Type 1 diabetesZinc transporter 8 autoantibodies (ZnT8A)ZnT8RA autoantibodiesZnT8WA autoantibodies

PubMed DOI Metascience Observatory

About MICB

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]