MICU2

mitochondrial calcium uptake 2

Summary

Enables several functions, including calcium channel regulator activity; calcium ion sensor activity; and protein heterodimerization activity. Involved in calcium import into the mitochondrion; cellular response to calcium ion; and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial intermembrane space. Part of uniplex complex. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants35 total

rsidPosition (GRCh37)AllelesClassClinVar
rs74975228313:22,067,411G/Cuncertain significance
rs36905981113:22,067,413T/Auncertain significance
rs123874353813:22,067,443T/Guncertain significance
rs254236769613:22,067,481A/Clikely benign
rs123213344113:22,069,371C/Tuncertain significance
rs148223856513:22,070,260T/Cuncertain significance
rs14550394513:22,077,081T/Alikely benign
rs14541085013:22,077,082T/Alikely benign
rs20186336413:22,077,143C/Auncertain significance
rs56126709513:22,084,194C/Tlikely benign
rs37370752413:22,095,425T/Clikely benign
rs254239420513:22,095,446C/Tuncertain significance
rs77937875013:22,096,772C/Tuncertain significance
rs1286977613:22,103,294A/Gupstream gene variant
rs279828013:22,112,853T/Cintron variant
rs13857109913:22,113,510C/Tuncertain significance
rs1161672013:22,115,822A/T
rs1184016813:22,118,302A/T
rs279826913:22,131,897C/Tintron variant
rs134930255413:22,140,959G/Auncertain significance
rs76152671813:22,141,021C/Auncertain significance
rs55504209913:22,141,037C/Tuncertain significance
rs77847410013:22,141,055A/Guncertain significance
rs77152411613:22,141,058T/Cuncertain significance
rs20138930913:22,178,086A/Cuncertain significance
rs143470241313:22,178,109G/Auncertain significance
rs18445100713:22,178,125G/Auncertain significance
rs75075619213:22,178,148G/Cuncertain significance
rs13993134313:22,178,149C/Glikely benign
rs76985728813:22,178,191C/Tuncertain significance
rs188890022413:22,178,227C/Guncertain significance
rs188890144813:22,178,246C/Tuncertain significance
rs137237856213:22,178,257C/Alikely benign
rs76427966513:22,178,276A/Glikely benign
rs92669688113:22,178,283G/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.