MIF
macrophage migration inhibitory factor
Summary
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Known Variants17 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4822446 | 22:24,235,360 | A/G | downstream gene variant | — |
| rs755622 | 22:24,236,392 | G/C | regulatory region variant | risk factor |
| rs112568463 | 22:24,236,588 | A/T | regulatory region variant | — |
| rs200500959 | 22:24,236,666 | C/G | — | uncertain significance |
| rs766674911 | 22:24,236,744 | C/T | — | uncertain significance |
| rs201631604 | 22:24,236,761 | C/A | — | uncertain significance |
| rs2096525 | 22:24,236,819 | T/C | regulatory region variant | — |
| rs372575900 | 22:24,236,992 | A/G | — | uncertain significance |
| rs761381011 | 22:24,237,022 | G/A | — | uncertain significance |
| rs532485317 | 22:24,237,045 | C/G | — | uncertain significance |
| rs754953765 | 22:24,237,054 | C/A | — | likely benign |
| rs928592489 | 22:24,237,070 | C/G | — | uncertain significance |
| rs2517310655 | 22:24,237,071 | G/T | — | uncertain significance |
| rs182012324 | 22:24,237,074 | C/T | — | likely benign |
| rs189811391 | 22:24,237,218 | C/T | — | benign |
| rs35625249 | 22:24,237,220 | C/A | — | benign |
| rs2070766 | 22:24,237,221 | C/G | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.