rs2070766

This variant is located in the MIF gene.

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ClinVar annotation

Benign
2 submitters

MIF-related disorder; Nonpapillary renal cell carcinoma; Familial cancer of breast; Thyroid cancer, nonmedullary, 1; Hepatocellular carcinoma; Uveal melanoma; Malignant lymphoma, large B-cell, diffuse; Glioma susceptibility 1; Uterine carcinosarcoma; Melanoma

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Research that mentions this SNP (1)

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Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case–Cohort Study, 1984–2002
AssociationN=2,134Herder C. et al.(2008)· Diabetologia

A prospective population-based case-cohort study of 502 type 2 diabetes cases and 1,632 non-cases examined the association between MIF gene variants, circulating MIF levels, and type 2 diabetes risk. The C allele of rs1007888 was associated with elevated MIF serum levels and increased type 2 diabetes risk in women (HR 1.74, 95% CI 1.02–2.97), particularly in obese women, suggesting a causal role for MIF in diabetes development via a Mendelian randomization approach.

Traits studied:Type 2 diabetes
PubMedDOIMetascience Observatory

About MIF

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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