MRC2
mannose receptor C-type 2
Summary
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Known Variants84 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs903828101 | 17:60,705,227 | C/T | — | uncertain significance |
| rs747486959 | 17:60,742,003 | C/A | — | uncertain significance |
| rs144985234 | 17:60,742,131 | G/A | — | uncertain significance |
| rs751226940 | 17:60,742,199 | C/T | — | uncertain significance |
| rs370889422 | 17:60,742,200 | G/A | — | uncertain significance |
| rs545953172 | 17:60,742,221 | C/T | — | uncertain significance |
| rs2544325559 | 17:60,742,253 | A/G | — | uncertain significance |
| rs116402606 | 17:60,742,254 | G/C | — | likely benign |
| rs113859572 | 17:60,742,307 | C/T | missense variant | — |
| rs2544327294 | 17:60,743,487 | A/G | — | uncertain significance |
| rs2544327397 | 17:60,743,542 | G/C | — | uncertain significance |
| rs1209039095 | 17:60,743,565 | C/G | — | uncertain significance |
| rs751829119 | 17:60,743,592 | G/A | — | uncertain significance |
| rs1292903689 | 17:60,743,593 | G/A | — | uncertain significance |
| rs757037788 | 17:60,743,605 | G/A | — | uncertain significance |
| rs770189073 | 17:60,743,894 | C/T | — | uncertain significance |
| rs750134590 | 17:60,743,951 | C/T | — | uncertain significance |
| rs747607974 | 17:60,744,230 | T/G | — | uncertain significance |
| rs146172137 | 17:60,744,831 | A/C | missense variant | — |
| rs770362047 | 17:60,749,027 | A/C | — | uncertain significance |
| rs201553090 | 17:60,749,093 | C/T | — | uncertain significance |
| rs2544335524 | 17:60,749,177 | A/C | — | uncertain significance |
| rs552462957 | 17:60,749,512 | C/T | — | uncertain significance |
| rs2088860153 | 17:60,751,471 | C/G | — | uncertain significance |
| rs977725755 | 17:60,751,498 | G/C | — | uncertain significance |
| rs151074691 | 17:60,753,158 | C/A | — | uncertain significance |
| rs200210214 | 17:60,753,220 | C/T | — | uncertain significance |
| rs770707362 | 17:60,753,237 | T/G | — | uncertain significance |
| rs551322802 | 17:60,753,821 | A/C | — | uncertain significance |
| rs777999565 | 17:60,753,847 | A/G | — | uncertain significance |
| rs750605988 | 17:60,753,880 | C/T | — | uncertain significance |
| rs1043662825 | 17:60,754,650 | G/A | — | uncertain significance |
| rs368111612 | 17:60,754,654 | C/T | — | uncertain significance |
| rs1290488542 | 17:60,754,659 | G/T | — | uncertain significance |
| rs544466816 | 17:60,754,671 | G/T | — | uncertain significance |
| rs754790541 | 17:60,754,710 | C/T | — | uncertain significance |
| rs752667622 | 17:60,754,716 | C/T | — | uncertain significance |
| rs756780814 | 17:60,754,729 | G/A | — | uncertain significance |
| rs745556889 | 17:60,754,753 | C/T | — | uncertain significance |
| rs775771345 | 17:60,754,756 | C/T | — | uncertain significance |
| rs528981977 | 17:60,754,780 | C/T | — | uncertain significance |
| rs766723148 | 17:60,754,819 | C/T | — | uncertain significance |
| rs763886887 | 17:60,754,833 | C/T | — | uncertain significance |
| rs757929356 | 17:60,755,880 | C/T | — | uncertain significance |
| rs1236685407 | 17:60,755,889 | G/T | — | uncertain significance |
| rs560090443 | 17:60,755,964 | G/C | — | uncertain significance |
| rs139690070 | 17:60,755,994 | A/C | — | uncertain significance |
| rs2544346962 | 17:60,757,187 | A/G | — | uncertain significance |
| rs780221773 | 17:60,757,229 | G/T | — | uncertain significance |
| rs772940657 | 17:60,757,787 | G/A | — | uncertain significance |
| rs201112479 | 17:60,757,821 | A/G | — | benign |
| rs2088956969 | 17:60,758,241 | A/C | — | uncertain significance |
| rs2460300 | 17:60,759,347 | A/C | upstream gene variant | — |
| rs766556463 | 17:60,759,604 | G/A | — | uncertain significance |
| rs371331099 | 17:60,759,733 | A/C | — | uncertain significance |
| rs12386061 | 17:60,763,400 | G/C | downstream gene variant | — |
| rs3786130 | 17:60,765,043 | T/C | downstream gene variant | — |
| rs773699855 | 17:60,765,683 | C/T | — | uncertain significance |
| rs200385260 | 17:60,766,005 | G/C | — | uncertain significance |
| rs150097171 | 17:60,766,023 | C/A | — | uncertain significance |
| rs144142657 | 17:60,766,292 | C/T | — | uncertain significance |
| rs200856511 | 17:60,766,319 | C/T | — | uncertain significance |
| rs142227716 | 17:60,766,927 | G/A | — | uncertain significance |
| rs774190435 | 17:60,766,982 | G/A | — | uncertain significance |
| rs960341741 | 17:60,767,014 | C/T | — | uncertain significance |
| rs376905774 | 17:60,767,020 | G/A | — | likely benign |
| rs143651722 | 17:60,767,078 | G/A | — | uncertain significance |
| rs56288724 | 17:60,767,135 | A/G | intron variant | — |
| rs2544365018 | 17:60,767,288 | C/G | — | uncertain significance |
| rs554348769 | 17:60,767,322 | C/T | — | uncertain significance |
| rs774312146 | 17:60,767,330 | C/T | — | uncertain significance |
| rs2544365254 | 17:60,767,387 | A/G | — | uncertain significance |
| rs2465426 | 17:60,767,461 | C/G | intron variant | — |
| rs199787567 | 17:60,767,526 | C/T | — | uncertain significance |
| rs569372444 | 17:60,767,541 | G/A | — | uncertain significance |
| rs201452476 | 17:60,767,547 | A/C | — | uncertain significance |
| rs554213482 | 17:60,767,618 | A/G | — | uncertain significance |
| rs143179241 | 17:60,767,649 | G/A | — | uncertain significance |
| rs3786132 | 17:60,768,921 | A/C | intron variant | — |
| rs35688424 | 17:60,769,406 | T/A | — | — |
| rs34850824 | 17:60,769,663 | G/A | — | benign |
| rs567602213 | 17:60,769,702 | C/T | — | uncertain significance |
| rs894053039 | 17:60,769,703 | G/A | — | uncertain significance |
| rs2544368761 | 17:60,769,736 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.