MRPL33
mitochondrial ribosomal protein L33
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Known Variants6 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs767904582 | 2:27,995,551 | C/G | — | uncertain significance |
| rs3736594 | 2:27,995,781 | A/G | — | — |
| rs2465353910 | 2:27,997,314 | G/C | — | uncertain significance |
| rs374780526 | 2:27,997,329 | G/A | — | uncertain significance |
| rs777018782 | 2:27,997,381 | G/C | — | uncertain significance |
| rs77829337 | 2:28,001,745 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.