MRPS24
mitochondrial ribosomal protein S24
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene and the upstream upregulator of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011]
Known Variants9 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2543325763 | 7:43,906,321 | T/C | — | uncertain significance |
| rs149618607 | 7:43,906,347 | C/T | — | uncertain significance |
| rs144323321 | 7:43,906,357 | A/G | — | uncertain significance |
| rs1246715802 | 7:43,906,365 | A/G | — | uncertain significance |
| rs531031859 | 7:43,906,516 | T/A | — | uncertain significance |
| rs370194870 | 7:43,906,525 | G/A | — | uncertain significance |
| rs763064827 | 7:43,906,564 | C/T | — | uncertain significance |
| rs372141101 | 7:43,908,950 | G/A | — | uncertain significance |
| rs10232743 | 7:43,910,882 | C/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.