MX2
MX dynamin like GTPase 2
Summary
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]
Known Variants57 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs554428087 | 21:42,733,729 | C/A | — | — |
| rs2838027 | 21:42,734,412 | A/G | regulatory region variant | — |
| rs398206 | 21:42,742,036 | A/C | — | benign |
| rs443099 | 21:42,743,327 | G/C | — | — |
| rs45430 | 21:42,746,081 | C/T | intron variant | — |
| rs751152408 | 21:42,748,867 | A/G | — | uncertain significance |
| rs369575235 | 21:42,748,908 | A/C | — | uncertain significance |
| rs773174691 | 21:42,748,928 | A/T | — | uncertain significance |
| rs767750801 | 21:42,749,077 | G/A | — | uncertain significance |
| rs2517033477 | 21:42,749,717 | G/A | — | uncertain significance |
| rs750379715 | 21:42,749,758 | C/T | — | uncertain significance |
| rs2517034154 | 21:42,749,813 | T/A | — | uncertain significance |
| rs147964158 | 21:42,749,833 | G/A | — | uncertain significance |
| rs527335705 | 21:42,749,839 | G/A | — | uncertain significance |
| rs764863320 | 21:42,751,994 | G/A | — | likely benign |
| rs768338740 | 21:42,752,057 | G/T | — | uncertain significance |
| rs2074560 | 21:42,752,338 | A/C | — | — |
| rs761174279 | 21:42,752,786 | C/T | — | — |
| rs374589570 | 21:42,754,364 | G/A | — | uncertain significance |
| rs1256075905 | 21:42,754,369 | A/G | — | uncertain significance |
| rs750645449 | 21:42,754,396 | A/G | — | uncertain significance |
| rs1187092680 | 21:42,754,424 | C/T | — | uncertain significance |
| rs764641355 | 21:42,754,441 | G/A | — | uncertain significance |
| rs1226009594 | 21:42,754,452 | G/T | — | uncertain significance |
| rs150127593 | 21:42,754,483 | G/A | — | uncertain significance |
| rs2517049490 | 21:42,754,487 | T/A | — | uncertain significance |
| rs756158339 | 21:42,762,501 | C/G | — | uncertain significance |
| rs138600033 | 21:42,762,528 | C/A | — | uncertain significance |
| rs1303776813 | 21:42,762,561 | G/A | — | uncertain significance |
| rs369056244 | 21:42,762,610 | C/T | — | uncertain significance |
| rs371266032 | 21:42,767,609 | A/G | — | uncertain significance |
| rs759310607 | 21:42,767,625 | G/A | — | uncertain significance |
| rs761026608 | 21:42,770,828 | C/T | — | uncertain significance |
| rs768433784 | 21:42,770,834 | C/T | — | uncertain significance |
| rs146547441 | 21:42,770,890 | C/T | — | uncertain significance |
| rs141083003 | 21:42,770,896 | G/A | — | likely benign |
| rs376728567 | 21:42,770,923 | G/A | — | uncertain significance |
| rs745448850 | 21:42,771,150 | G/A | — | uncertain significance |
| rs2517097750 | 21:42,771,184 | A/C | — | uncertain significance |
| rs367899823 | 21:42,771,196 | G/A | — | uncertain significance |
| rs189548312 | 21:42,773,914 | G/A | — | uncertain significance |
| rs2517108525 | 21:42,773,969 | T/C | — | uncertain significance |
| rs1305398674 | 21:42,774,002 | A/G | — | uncertain significance |
| rs1223361578 | 21:42,774,034 | A/G | — | uncertain significance |
| rs752224352 | 21:42,774,040 | C/T | — | uncertain significance |
| rs149631739 | 21:42,775,220 | G/A | — | likely benign |
| rs2089839904 | 21:42,775,223 | G/T | — | uncertain significance |
| rs1170842674 | 21:42,775,241 | G/A | — | uncertain significance |
| rs142430088 | 21:42,775,263 | C/G | — | uncertain significance |
| rs758411744 | 21:42,778,678 | T/C | — | uncertain significance |
| rs146535907 | 21:42,778,813 | A/G | — | uncertain significance |
| rs777289479 | 21:42,778,867 | A/G | — | uncertain significance |
| rs149739484 | 21:42,779,936 | G/A | — | uncertain significance |
| rs749653296 | 21:42,780,014 | A/T | — | likely benign |
| rs761593917 | 21:42,780,061 | T/C | — | likely benign |
| rs368409724 | 21:42,780,120 | G/A | — | uncertain significance |
| rs780046886 | 21:42,780,125 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.