NAP1L4
nucleosome assembly protein 1 like 4
Summary
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs769631205 | 11:2,972,539 | C/G | — | uncertain significance |
| rs2493767122 | 11:2,975,851 | G/A | — | uncertain significance |
| rs200489621 | 11:2,979,640 | T/C | — | likely benign |
| rs370527709 | 11:2,979,664 | T/A | — | uncertain significance |
| rs201761556 | 11:2,979,679 | G/A | — | uncertain significance |
| rs191946473 | 11:2,979,767 | T/C | — | uncertain significance |
| rs2493803976 | 11:2,981,121 | G/C | — | uncertain significance |
| rs7127443 | 11:2,985,541 | A/T | — | — |
| rs752080473 | 11:2,985,912 | T/C | — | uncertain significance |
| rs1163458221 | 11:2,985,968 | G/A | — | uncertain significance |
| rs7109587 | 11:2,988,239 | A/T | — | — |
| rs11603638 | 11:2,990,526 | G/A | intron variant | — |
| rs930988016 | 11:2,991,046 | C/T | — | uncertain significance |
| rs1304210424 | 11:2,991,066 | G/C | — | uncertain significance |
| rs765130655 | 11:2,991,071 | T/C | — | uncertain significance |
| rs754415348 | 11:2,991,118 | G/A | — | uncertain significance |
| rs367863841 | 11:2,992,701 | T/C | — | uncertain significance |
| rs1847632336 | 11:2,992,703 | T/C | — | uncertain significance |
| rs2493893434 | 11:2,992,727 | T/C | — | uncertain significance |
| rs16928946 | 11:2,992,747 | G/A | — | benign |
| rs35073985 | 11:2,993,409 | T/C | — | uncertain significance |
| rs1418994742 | 11:2,993,466 | T/C | — | uncertain significance |
| rs778280720 | 11:2,997,261 | T/C | — | uncertain significance |
| rs1391403314 | 11:2,997,296 | C/T | — | uncertain significance |
| rs374123149 | 11:2,997,320 | C/T | — | likely benign |
| rs367931607 | 11:2,997,333 | T/C | — | uncertain significance |
| rs375368938 | 11:2,999,531 | T/G | — | uncertain significance |
| rs375706072 | 11:2,999,556 | G/T | — | uncertain significance |
| rs1468102 | 11:3,004,526 | C/A | — | — |
| rs12806061 | 11:3,008,404 | G/A | upstream gene variant | — |
| rs61063671 | 11:3,009,024 | G/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.