NCOR1

nuclear receptor corepressor 1

Summary

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

Known Variants160 total

rsidPosition (GRCh37)AllelesClassClinVar
rs991686817:15,932,820G/Cdownstream gene variant—
rs75297689917:15,935,731A/G—uncertain significance
rs255002330517:15,935,767G/A—uncertain significance
rs159754930317:15,938,110C/T—likely benign
rs14189686417:15,938,140T/C—benign
rs77963626517:15,938,174G/A—uncertain significance
rs255015160117:15,938,187C/G—uncertain significance
rs14627262417:15,938,257T/C—likely benign
rs75213064617:15,942,763G/T—uncertain significance
rs78149667617:15,942,768C/T—uncertain significance
rs13914978117:15,942,832C/T—likely benign
rs20070277117:15,942,869T/C—uncertain significance
rs56444257117:15,942,885C/T—uncertain significance
rs14992106917:15,942,929G/C—uncertain significance
rs255030057917:15,942,966A/C—uncertain significance
rs479271617:15,943,144A/Gupstream gene variant—
rs57117422817:15,943,760G/A—uncertain significance
rs52787140317:15,950,266C/T—likely benign
rs6175314917:15,950,400C/T—benign
rs74634910917:15,952,178C/T—uncertain significance
rs14773459017:15,952,227C/T—benign
rs14448034617:15,952,254G/A—benign
rs11500568817:15,952,299C/T—benign
rs206007778217:15,960,849A/G—uncertain significance
rs255075926317:15,960,888T/G—uncertain significance
rs14568645717:15,960,908T/C—likely benign
rs255076221417:15,960,951G/A—uncertain significance
rs14271754517:15,961,011G/A—uncertain significance
rs11561429017:15,961,224G/T—benign
rs255077224117:15,961,246A/G—uncertain significance
rs136261653017:15,961,295G/C—uncertain significance
rs77733818017:15,961,316A/G—uncertain significance
rs20072232917:15,961,336C/T—uncertain significance
rs19323995717:15,961,779A/G—likely benign
rs76287461717:15,961,790G/A—uncertain significance
rs7655590917:15,961,825C/T—benign
rs145404709217:15,961,833T/G—uncertain significance
rs20015808917:15,961,841G/A—uncertain significance
rs100489289617:15,961,856C/T—uncertain significance
rs145252111517:15,964,756G/A—uncertain significance
rs1294268417:15,964,765T/A—uncertain significance
rs206055008117:15,964,879T/C—uncertain significance
rs74788668817:15,964,939G/C—uncertain significance
rs20210476117:15,964,964C/T—uncertain significance
rs206055712817:15,964,969C/G—uncertain significance
rs206055855817:15,964,985G/C—uncertain significance
rs116748296517:15,965,189G/A—uncertain significance
rs20004511317:15,965,507T/C—uncertain significance
rs1165202517:15,965,863T/Gintron variant—
rs77678310317:15,967,395G/A—likely benign
rs75155948617:15,967,426C/T—uncertain significance
rs96973798917:15,967,446C/T—likely benign
rs37321650717:15,967,451G/A—uncertain significance
rs120449165317:15,967,454C/T—uncertain significance
rs78150480517:15,967,493T/C—uncertain significance
rs20044027417:15,968,199C/G—uncertain significance
rs37769837217:15,968,209C/T—likely benign
rs255092043617:15,968,862C/T—uncertain significance
rs721005717:15,968,887T/C—benign
rs76231816417:15,968,937C/T—uncertain significance
rs255094420617:15,971,225T/C—uncertain significance
rs121596205517:15,971,268G/A—uncertain significance
rs15131106717:15,971,357G/A—uncertain significance
rs76352931617:15,971,379T/A—uncertain significance
rs215272173617:15,973,487G/A—uncertain significance
rs11345822517:15,973,520G/A—uncertain significance
rs145529451617:15,973,595G/A—uncertain significance
rs255099493217:15,973,637A/G—uncertain significance
rs13870398417:15,973,663G/A—benign
rs36818418617:15,973,748C/T—uncertain significance
rs6175315017:15,973,774T/G—benign
rs138118459917:15,973,790T/C—uncertain significance
rs1294229517:15,973,844A/T—benign
rs7969385517:15,974,831C/T—benign
rs76865792817:15,974,895G/A—uncertain significance
rs96451870417:15,974,907G/A—uncertain significance
rs255103117417:15,974,934T/A—uncertain significance
rs36944054017:15,976,793A/G—uncertain significance
rs37565623217:15,976,830T/C—uncertain significance
rs13945853217:15,976,868C/T—likely benign
rs76759201917:15,976,883T/C—uncertain significance
rs255107811817:15,978,878C/T—uncertain significance
rs76512736117:15,983,282G/C—uncertain significance
rs129920934317:15,983,288G/C—uncertain significance
rs6175315117:15,983,343G/T—likely benign
rs75239064017:15,983,364T/C—uncertain significance
rs15051310517:15,983,784C/T—benign
rs206322558417:15,983,806T/C—uncertain significance
rs206322722517:15,983,813G/A—likely benign
rs215281586717:15,983,821T/C—uncertain significance
rs14658462817:15,983,963T/C—uncertain significance
rs7605716917:15,983,970C/T—benign
rs123754118217:15,983,977G/A—uncertain significance
rs37652236017:15,989,645G/A—uncertain significance
rs119989216617:15,989,690C/T—uncertain significance
rs206423229317:15,989,700G/A—uncertain significance
rs37148387217:15,989,709C/T—uncertain significance
rs76906617417:15,995,200T/C—uncertain significance
rs142926208817:15,995,303T/C—uncertain significance
rs129633798817:15,995,323T/A—uncertain significance

Showing 100 of 160 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.