NEDD9
neural precursor cell expressed, developmentally down-regulated 9
Summary
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1803710 | 6:11,184,867 | C/A | 3 prime UTR variant | — |
| rs548245377 | 6:11,185,424 | G/A | — | uncertain significance |
| rs751545988 | 6:11,185,504 | A/C | — | uncertain significance |
| rs558466063 | 6:11,185,532 | T/C | — | uncertain significance |
| rs762829138 | 6:11,185,582 | C/T | — | uncertain significance |
| rs758922320 | 6:11,185,663 | C/A | — | uncertain significance |
| rs769283197 | 6:11,185,679 | T/G | — | uncertain significance |
| rs202065635 | 6:11,185,723 | A/G | — | uncertain significance |
| rs2480621249 | 6:11,185,748 | G/A | — | uncertain significance |
| rs142392451 | 6:11,185,786 | C/A | — | uncertain significance |
| rs759740305 | 6:11,185,814 | T/G | — | uncertain significance |
| rs753011902 | 6:11,185,820 | G/A | — | uncertain significance |
| rs758259305 | 6:11,185,862 | C/T | — | uncertain significance |
| rs144637323 | 6:11,185,863 | G/A | — | likely benign |
| rs112742585 | 6:11,188,458 | T/C | — | uncertain significance |
| rs1758028457 | 6:11,188,532 | C/G | — | uncertain significance |
| rs146864079 | 6:11,190,203 | G/A | — | likely benign |
| rs775094801 | 6:11,190,208 | C/T | — | uncertain significance |
| rs149528492 | 6:11,190,265 | G/A | — | uncertain significance |
| rs143967808 | 6:11,190,359 | G/A | — | benign |
| rs139703680 | 6:11,190,408 | T/C | — | uncertain significance |
| rs1581942595 | 6:11,190,514 | G/C | — | uncertain significance |
| rs150123400 | 6:11,190,591 | T/C | — | likely benign |
| rs2480632423 | 6:11,190,618 | G/T | — | uncertain significance |
| rs2480633089 | 6:11,190,792 | C/T | — | uncertain significance |
| rs371876294 | 6:11,190,823 | G/T | — | uncertain significance |
| rs748028305 | 6:11,190,918 | G/A | — | uncertain significance |
| rs535503432 | 6:11,190,972 | C/T | — | uncertain significance |
| rs778807338 | 6:11,191,027 | G/A | — | uncertain significance |
| rs746023756 | 6:11,191,048 | G/T | — | uncertain significance |
| rs1486160416 | 6:11,191,090 | G/A | — | uncertain significance |
| rs1166640309 | 6:11,191,105 | T/A | — | uncertain significance |
| rs200047696 | 6:11,191,135 | C/T | — | uncertain significance |
| rs1758123116 | 6:11,191,155 | G/A | — | uncertain significance |
| rs369820835 | 6:11,191,231 | C/T | — | uncertain significance |
| rs550083116 | 6:11,191,236 | G/A | — | likely benign |
| rs149032299 | 6:11,191,291 | C/G | — | uncertain significance |
| rs781622312 | 6:11,191,332 | G/A | — | uncertain significance |
| rs201994291 | 6:11,191,363 | T/C | — | uncertain significance |
| rs2480634958 | 6:11,191,389 | T/G | — | uncertain significance |
| rs781704547 | 6:11,191,410 | C/T | — | uncertain significance |
| rs376139978 | 6:11,191,438 | C/T | — | uncertain significance |
| rs767880483 | 6:11,192,618 | A/C | — | uncertain significance |
| rs140836210 | 6:11,192,648 | C/T | — | uncertain significance |
| rs2480638907 | 6:11,192,661 | A/T | — | uncertain significance |
| rs780993452 | 6:11,192,673 | C/T | — | uncertain significance |
| rs1758839521 | 6:11,213,521 | C/T | — | uncertain significance |
| rs748674458 | 6:11,213,540 | T/C | — | likely benign |
| rs763936432 | 6:11,213,600 | C/T | — | uncertain significance |
| rs2480685955 | 6:11,213,614 | A/G | — | uncertain significance |
| rs761694099 | 6:11,213,749 | T/A | — | uncertain significance |
| rs770931575 | 6:11,213,750 | C/G | — | uncertain significance |
| rs1758856406 | 6:11,213,874 | T/C | — | uncertain significance |
| rs11961171 | 6:11,276,028 | G/A | regulatory region variant | — |
| rs4713343 | 6:11,289,748 | C/T | intron variant | — |
| rs4437462 | 6:11,310,419 | C/T | regulatory region variant | — |
| rs760678 | 6:11,334,654 | C/A | — | — |
| rs181930706 | 6:11,378,202 | G/A | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.