rs1803710

This is a 3 prime utr variant variant in the NEDD9 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Facial wrinkling

Chen Y et al. “A genome-wide association study identifies novel gene associations with facial skin wrinkling and mole count in Latin Americans.” The British Journal of Dermatology 185(5):988-998 (2021)

Allele C

OR 0.14

p 3.0e-8

N 6,254

Large GWAS

Hispanic or Latin American

About NEDD9

The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

View all NEDD9 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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