NEK10
NIMA related kinase 10
Summary
Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants67 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs768169562 | 3:27,157,448 | G/T | — | conflicting classifications of pathogenicity |
| rs1851366 | 3:27,194,844 | T/C | intron variant | — |
| rs55644439 | 3:27,195,705 | A/T | intron variant | — |
| rs17854381 | 3:27,204,052 | G/A | — | benign |
| rs770055117 | 3:27,215,952 | G/T | — | uncertain significance |
| rs11926556 | 3:27,233,498 | C/A | — | benign |
| rs774551711 | 3:27,233,594 | G/A | — | uncertain significance |
| rs766982731 | 3:27,233,708 | G/A | — | pathogenic |
| rs34344159 | 3:27,233,716 | A/G | — | benign |
| rs17680166 | 3:27,243,045 | G/C | — | benign |
| rs1575215909 | 3:27,243,049 | G/A | — | pathogenic |
| rs764245230 | 3:27,243,957 | G/A | — | likely pathogenic |
| rs763059195 | 3:27,257,232 | G/A | — | likely benign |
| rs186052913 | 3:27,285,042 | G/A | intron variant | — |
| rs3213930 | 3:27,297,816 | G/C | — | benign |
| rs11129280 | 3:27,326,097 | G/T | — | benign |
| rs55833401 | 3:27,326,131 | T/C | — | benign |
| rs769418963 | 3:27,326,431 | A/G | — | uncertain significance |
| rs10510594 | 3:27,326,451 | G/A | — | benign |
| rs481519 | 3:27,327,214 | C/T | intron variant | — |
| rs370504122 | 3:27,332,149 | C/T | — | uncertain significance |
| rs2042933089 | 3:27,332,158 | C/T | — | uncertain significance |
| rs746153882 | 3:27,332,164 | C/T | — | uncertain significance |
| rs775814023 | 3:27,332,172 | T/C | — | uncertain significance |
| rs674303 | 3:27,332,177 | T/C | — | benign |
| rs752678613 | 3:27,332,235 | T/C | — | likely benign |
| rs10510592 | 3:27,332,820 | A/G | — | benign |
| rs751998633 | 3:27,332,871 | A/G | — | uncertain significance |
| rs768059523 | 3:27,333,033 | T/G | — | uncertain significance |
| rs200628958 | 3:27,335,089 | G/C | — | uncertain significance |
| rs188865423 | 3:27,335,141 | A/C | — | uncertain significance |
| rs2149500688 | 3:27,335,142 | C/A | — | uncertain significance |
| rs553960257 | 3:27,337,165 | G/A | — | uncertain significance |
| rs1253689023 | 3:27,338,665 | C/G | — | likely pathogenic |
| rs372412417 | 3:27,338,683 | T/A | — | uncertain significance |
| rs141057699 | 3:27,338,698 | T/C | — | benign |
| rs2149538816 | 3:27,343,223 | T/C | — | uncertain significance |
| rs75891446 | 3:27,343,261 | C/T | — | likely benign |
| rs653465 | 3:27,343,644 | C/T | intron variant | — |
| rs368039830 | 3:27,346,231 | T/C | — | likely benign |
| rs371174806 | 3:27,346,280 | C/T | — | uncertain significance |
| rs772648828 | 3:27,346,281 | G/A | — | uncertain significance |
| rs1176031701 | 3:27,346,287 | C/T | — | uncertain significance |
| rs2472445804 | 3:27,346,301 | G/A | — | uncertain significance |
| rs2044112024 | 3:27,346,322 | A/G | — | uncertain significance |
| rs2472448668 | 3:27,346,387 | T/C | — | uncertain significance |
| rs747494687 | 3:27,346,437 | G/A | — | uncertain significance |
| rs2472508163 | 3:27,349,381 | T/C | — | uncertain significance |
| rs35450418 | 3:27,350,471 | C/T | — | uncertain significance |
| rs646157 | 3:27,352,143 | T/C | — | — |
| rs537674 | 3:27,361,901 | G/A | — | — |
| rs141505128 | 3:27,363,710 | C/A | — | likely benign |
| rs2470532874 | 3:27,363,733 | G/A | — | uncertain significance |
| rs640065 | 3:27,363,937 | T/A | intron variant | — |
| rs1380257358 | 3:27,385,777 | A/C | — | uncertain significance |
| rs200401044 | 3:27,385,817 | C/T | — | likely benign |
| rs370830759 | 3:27,385,818 | G/T | — | uncertain significance |
| rs766619923 | 3:27,387,625 | C/T | — | uncertain significance |
| rs374317588 | 3:27,387,626 | G/A | — | uncertain significance |
| rs55958314 | 3:27,387,641 | C/T | — | likely benign |
| rs1165409897 | 3:27,387,646 | C/A | — | uncertain significance |
| rs112238765 | 3:27,388,820 | C/A | intron variant | — |
| rs151116557 | 3:27,393,958 | G/C | — | uncertain significance |
| rs1559548990 | 3:27,393,984 | A/C | — | uncertain significance |
| rs534489829 | 3:27,394,015 | C/T | — | uncertain significance |
| rs12494966 | 3:27,394,419 | T/G | — | benign |
| rs11715126 | 3:27,401,247 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.