NFIB

nuclear factor I B

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development and regulation of DNA-templated transcription. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants106 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs548618850	9:14,088,119	T/A	—	likely benign
rs2118462290	9:14,088,210	C/G	—	uncertain significance
rs376682001	9:14,088,247	G/A	—	likely benign
rs1011357372	9:14,113,000	G/A	—	likely pathogenic
rs759415688	9:14,113,017	G/T	—	uncertain significance
rs1404794342	9:14,113,042	C/T	—	uncertain significance
rs1203505870	9:14,113,075	T/C	—	uncertain significance
rs753551959	9:14,116,246	T/G	—	conflicting classifications of pathogenicity
rs1191193223	9:14,116,261	G/A	—	uncertain significance
rs1301800978	9:14,116,285	G/T	—	uncertain significance
rs539752814	9:14,116,299	G/C	—	likely benign
rs1358003647	9:14,116,312	G/A	—	uncertain significance
rs72698746	9:14,116,327	C/G	—	likely benign
rs750060639	9:14,120,467	T/C	—	uncertain significance
rs1586826467	9:14,120,479	T/C	—	uncertain significance
rs2537828479	9:14,120,501	G/C	—	uncertain significance
rs2038781074	9:14,120,537	A/G	—	uncertain significance
rs746059013	9:14,120,547	C/T	—	likely benign
rs2119150843	9:14,120,548	G/C	—	uncertain significance
rs146489320	9:14,120,553	G/A	—	likely benign
rs2119151075	9:14,120,563	A/G	—	uncertain significance
rs2537829352	9:14,120,566	A/C	—	uncertain significance
rs749973345	9:14,120,597	G/A	—	uncertain significance
rs1554639196	9:14,120,617	G/A	—	uncertain significance
rs766038266	9:14,120,622	G/A	—	likely benign
rs2537830164	9:14,120,624	C/G	—	likely pathogenic
rs1003216446	9:14,125,660	T/C	—	uncertain significance
rs375951326	9:14,125,665	G/C	—	uncertain significance
rs2537886294	9:14,125,702	T/C	—	uncertain significance
rs544162821	9:14,125,736	G/C	—	uncertain significance
rs992922055	9:14,125,765	T/A	—	uncertain significance
rs376568610	9:14,125,769	C/T	—	uncertain significance
rs2042310864	9:14,146,700	C/G	—	uncertain significance
rs1364033144	9:14,146,712	G/A	—	pathogenic
rs144909299	9:14,146,714	C/T	—	likely benign
rs1563833243	9:14,146,736	G/C	—	uncertain significance
rs1268417773	9:14,146,743	G/T	—	pathogenic
rs2538098365	9:14,146,769	C/A	—	pathogenic
rs746829464	9:14,146,784	T/C	—	uncertain significance
rs2538133361	9:14,150,141	T/G	—	uncertain significance
rs1030067060	9:14,150,151	G/C	—	uncertain significance
rs1359490761	9:14,150,163	G/C	—	uncertain significance
rs2538133914	9:14,150,181	C/G	—	likely benign
rs747872784	9:14,150,186	G/A	—	uncertain significance
rs916041028	9:14,150,228	A/G	—	uncertain significance
rs775490248	9:14,150,229	T/C	—	uncertain significance
rs368309534	9:14,150,263	C/T	—	likely benign
rs2538135168	9:14,150,266	T/C	—	pathogenic
rs61754991	9:14,155,846	T/C	—	likely benign
rs2538187914	9:14,155,848	A/T	—	uncertain significance
rs369406588	9:14,155,852	A/G	—	likely benign
rs1199102596	9:14,155,853	T/C	—	uncertain significance
rs147077516	9:14,155,888	G/A	—	likely benign
rs2537586929	9:14,179,722	T/C	—	uncertain significance
rs748665864	9:14,179,748	A/C	—	uncertain significance
rs4741351	9:14,222,782	A/T	—	—
rs145183241	9:14,244,689	A/G	intron variant	—
rs140086663	9:14,294,631	G/C	intron variant	—
rs2538991046	9:14,306,987	C/T	—	uncertain significance
rs2060055229	9:14,306,993	T/C	—	uncertain significance
rs1306896140	9:14,306,996	T/C	—	uncertain significance
rs1363394549	9:14,307,000	C/T	—	uncertain significance
rs2538991448	9:14,307,055	C/A	—	uncertain significance
rs11543132	9:14,307,131	C/A	—	uncertain significance
rs2132702460	9:14,307,134	T/C	—	uncertain significance
rs1554709654	9:14,307,155	A/G	—	pathogenic
rs2538992203	9:14,307,158	T/C	—	uncertain significance
rs2060062099	9:14,307,164	C/T	—	conflicting classifications of pathogenicity
rs1554709662	9:14,307,174	T/C	—	pathogenic
rs2132702648	9:14,307,183	G/A	—	likely pathogenic
rs966707448	9:14,307,186	G/A	—	pathogenic
rs1554709683	9:14,307,209	T/G	—	pathogenic
rs2538992538	9:14,307,210	T/C	—	likely pathogenic
rs2538992582	9:14,307,222	C/T	—	uncertain significance
rs202070696	9:14,307,223	G/A	—	likely benign
rs375679999	9:14,307,264	C/T	—	uncertain significance
rs764333096	9:14,307,285	G/A	—	pathogenic
rs370563581	9:14,307,296	C/A	—	likely benign
rs2132703494	9:14,307,314	T/C	—	uncertain significance
rs2538993532	9:14,307,320	A/C	—	uncertain significance
rs2060069576	9:14,307,349	T/A	—	uncertain significance
rs140030018	9:14,307,354	G/C	—	benign
rs2132704082	9:14,307,408	G/A	—	pathogenic
rs1588253471	9:14,307,435	G/A	—	pathogenic
rs1554709792	9:14,307,441	G/A	—	pathogenic
rs2538994371	9:14,307,464	T/C	—	uncertain significance
rs2060074543	9:14,307,467	G/A	—	likely pathogenic
rs1265735904	9:14,307,531	A/T	—	uncertain significance
rs771277912	9:14,313,472	G/C	—	uncertain significance
rs2539031037	9:14,313,480	C/T	—	uncertain significance
rs2539031292	9:14,313,509	A/G	—	uncertain significance
rs546452680	9:14,321,963	A/G	—	likely benign
rs2132874132	9:14,341,095	C/T	—	uncertain significance
rs10116194	9:14,394,112	A/G	intron variant	—
rs114558598	9:14,398,561	T/A	—	benign
rs907607515	9:14,398,611	G/C	—	uncertain significance
rs1041889853	9:14,398,630	T/A	—	uncertain significance
rs59677118	9:14,441,677	G/A	intergenic variant	—
rs10124571	9:14,442,490	C/T	regulatory region variant	—
rs1556032	9:14,446,001	C/T	intergenic variant	—

Showing 100 of 106 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.