NFIX

nuclear factor I X

Summary

The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Known Variants285 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2145117323	19:13,106,652	A/G	—	uncertain significance
rs2011445354	19:13,106,677	A/C	—	uncertain significance
rs189556314	19:13,106,791	C/T	—	likely benign
rs118040169	19:13,109,531	A/G	intron variant	—
rs10411958	19:13,113,641	T/A	—	—
rs146574056	19:13,118,710	C/G	regulatory region variant	—
rs1058993	19:13,134,501	A/T	—	likely benign
rs77959013	19:13,135,033	G/A	—	likely benign
rs73507341	19:13,135,197	T/C	—	benign
rs185692550	19:13,135,334	G/C	—	likely benign
rs959655759	19:13,135,444	G/C	—	uncertain significance
rs1450179895	19:13,135,459	A/T	—	likely benign
rs1024948492	19:13,135,465	G/A	—	likely benign
rs1042748505	19:13,135,467	G/T	—	likely benign
rs777153883	19:13,135,480	G/A	—	likely benign
rs1368994635	19:13,135,508	C/T	—	likely benign
rs998615133	19:13,135,509	G/A	—	benign
rs746605678	19:13,135,513	A/G	—	likely benign
rs2013212122	19:13,135,819	G/A	—	conflicting classifications of pathogenicity
rs1411538725	19:13,135,820	G/A	—	benign
rs747333782	19:13,135,840	G/A	—	likely benign
rs2512742307	19:13,135,841	T/C	—	uncertain significance
rs1041237175	19:13,135,848	C/G	—	uncertain significance
rs966713031	19:13,135,849	G/A	—	likely benign
rs559433211	19:13,135,855	C/T	—	likely benign
rs2512742471	19:13,135,856	G/T	—	pathogenic
rs1253804251	19:13,135,862	C/T	—	likely benign
rs770391394	19:13,135,873	C/T	—	likely benign
rs2512742582	19:13,135,874	G/C	—	uncertain significance
rs368774795	19:13,135,879	C/T	—	likely benign
rs2013220977	19:13,135,891	C/A	—	pathogenic
rs2512742803	19:13,135,894	C/G	—	likely benign
rs1252623910	19:13,135,895	T/A	—	likely pathogenic
rs2512742870	19:13,135,902	A/G	—	uncertain significance
rs761426805	19:13,135,912	G/A	—	likely benign
rs2013223468	19:13,135,920	G/A	—	pathogenic
rs148229471	19:13,135,924	G/A	—	likely benign
rs760493118	19:13,135,927	C/G	—	pathogenic
rs2512743076	19:13,135,931	A/G	—	uncertain significance
rs766284677	19:13,135,936	G/A	—	likely benign
rs2145191308	19:13,135,937	C/G	—	likely pathogenic
rs1568268397	19:13,135,943	A/T	—	pathogenic
rs1599737654	19:13,135,945	G/A	—	likely benign
rs375719449	19:13,135,948	G/A	—	likely benign
rs758504284	19:13,135,949	A/G	—	conflicting classifications of pathogenicity
rs1555696484	19:13,135,950	T/A	—	pathogenic
rs2512743342	19:13,135,953	C/T	—	uncertain significance
rs2145191499	19:13,135,955	A/T	—	pathogenic
rs150443437	19:13,135,960	C/G	—	likely benign
rs1555696499	19:13,135,961	G/T	—	pathogenic
rs1483937187	19:13,135,968	G/A	—	uncertain significance
rs1227553375	19:13,135,973	G/T	—	uncertain significance
rs2145191691	19:13,135,982	G/A	—	likely pathogenic
rs387907254	19:13,135,986	T/C	missense variant	pathogenic
rs369196245	19:13,135,990	G/A	—	likely benign
rs1057523001	19:13,135,993	C/G	—	likely benign
rs2013234045	19:13,135,994	G/T	—	pathogenic
rs2013235237	19:13,136,016	A/G	—	uncertain significance
rs770170081	19:13,136,027	C/G	—	uncertain significance
rs541802079	19:13,136,029	G/A	—	likely benign
rs2013237448	19:13,136,037	C/G	—	uncertain significance
rs761183873	19:13,136,038	C/T	—	likely benign
rs1599738036	19:13,136,039	A/T	—	pathogenic
rs2512744263	19:13,136,042	C/T	—	likely benign
rs2512744292	19:13,136,043	T/C	—	pathogenic
rs769513682	19:13,136,059	G/T	—	likely benign
rs1292104474	19:13,136,062	C/T	—	likely benign
rs2512744750	19:13,136,094	C/G	—	uncertain significance
rs765042055	19:13,136,095	G/A	—	likely benign
rs781518589	19:13,136,110	C/G	—	likely benign
rs376885081	19:13,136,116	C/G	—	uncertain significance
rs2013246660	19:13,136,123	T/C	—	likely pathogenic
rs2512745237	19:13,136,124	C/T	—	pathogenic
rs2145192459	19:13,136,132	G/T	—	pathogenic
rs1555696595	19:13,136,133	A/C	—	uncertain significance
rs2145192509	19:13,136,142	G/T	—	conflicting classifications of pathogenicity
rs2512745587	19:13,136,143	C/T	—	benign
rs1555696597	19:13,136,144	A/G	—	likely pathogenic
rs1599738398	19:13,136,151	G/A	—	pathogenic
rs1555696603	19:13,136,153	C/T	—	pathogenic
rs2145192570	19:13,136,154	G/A	—	pathogenic
rs1555696606	19:13,136,155	G/C	—	likely benign
rs2512745827	19:13,136,162	T/C	—	likely pathogenic
rs1599738438	19:13,136,164	C/T	—	likely benign
rs2512745878	19:13,136,166	T/G	—	uncertain significance
rs369056833	19:13,136,167	G/A	—	likely benign
rs797044911	19:13,136,168	C/T	missense variant	pathogenic
rs387907255	19:13,136,169	G/C	missense variant	pathogenic
rs2013252632	19:13,136,177	G/A	—	uncertain significance
rs2145192745	19:13,136,180	A/G	—	pathogenic
rs2013253145	19:13,136,186	T/C	—	uncertain significance
rs2145192782	19:13,136,188	G/T	—	likely pathogenic
rs2145192793	19:13,136,190	G/A	—	likely pathogenic
rs2512746132	19:13,136,191	G/A	—	likely benign
rs200313486	19:13,136,200	G/A	—	likely benign
rs2145192919	19:13,136,201	G/T	—	pathogenic
rs2512746313	19:13,136,205	T/C	—	uncertain significance
rs929589127	19:13,136,207	G/T	—	conflicting classifications of pathogenicity
rs976653460	19:13,136,208	T/C	—	uncertain significance
rs2512746375	19:13,136,217	T/C	—	uncertain significance

Showing 100 of 285 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.