NFKBIZ
NFKB inhibitor zeta
Summary
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Known Variants43 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs17347644 | 3:101,547,733 | C/G | — | — |
| rs645781 | 3:101,562,980 | G/C | — | — |
| rs748115613 | 3:101,568,512 | G/C | — | uncertain significance |
| rs189392097 | 3:101,568,645 | C/T | — | uncertain significance |
| rs1301803161 | 3:101,568,647 | G/A | — | uncertain significance |
| rs749241699 | 3:101,568,714 | C/T | — | likely benign |
| rs755421482 | 3:101,568,717 | T/C | — | uncertain significance |
| rs779117101 | 3:101,568,755 | C/A | — | likely benign |
| rs616597 | 3:101,569,726 | A/G | — | — |
| rs600718 | 3:101,570,375 | A/C | — | — |
| rs781316486 | 3:101,571,015 | C/T | — | uncertain significance |
| rs145163386 | 3:101,571,028 | A/G | — | uncertain significance |
| rs756161368 | 3:101,571,741 | A/G | — | uncertain significance |
| rs1277017860 | 3:101,571,792 | C/A | — | uncertain significance |
| rs201726156 | 3:101,571,959 | G/A | — | uncertain significance |
| rs370141285 | 3:101,571,963 | A/G | — | uncertain significance |
| rs150091528 | 3:101,572,097 | G/A | — | uncertain significance |
| rs201178299 | 3:101,572,121 | G/A | — | uncertain significance |
| rs138359479 | 3:101,572,167 | C/T | — | uncertain significance |
| rs1312913255 | 3:101,572,194 | G/C | — | uncertain significance |
| rs146210819 | 3:101,572,221 | C/T | — | uncertain significance |
| rs749258201 | 3:101,572,230 | A/G | — | uncertain significance |
| rs199980845 | 3:101,572,310 | C/T | — | likely benign |
| rs780913282 | 3:101,572,311 | C/G | — | uncertain significance |
| rs146355720 | 3:101,572,317 | C/G | — | uncertain significance |
| rs2472085750 | 3:101,572,372 | T/G | — | uncertain significance |
| rs371473438 | 3:101,572,392 | T/C | — | likely benign |
| rs777889601 | 3:101,572,431 | C/G | — | uncertain significance |
| rs200989995 | 3:101,572,544 | T/G | — | uncertain significance |
| rs2472086186 | 3:101,572,547 | G/T | — | uncertain significance |
| rs2472086348 | 3:101,572,656 | T/C | — | uncertain significance |
| rs1038828502 | 3:101,572,662 | A/G | — | uncertain significance |
| rs201022850 | 3:101,572,682 | C/G | — | uncertain significance |
| rs776273958 | 3:101,573,432 | A/G | — | uncertain significance |
| rs677011 | 3:101,574,503 | G/A | regulatory region variant | — |
| rs781001372 | 3:101,574,696 | G/A | — | uncertain significance |
| rs778159031 | 3:101,574,733 | C/T | — | uncertain significance |
| rs140077856 | 3:101,575,921 | G/A | — | uncertain significance |
| rs1943060428 | 3:101,575,939 | C/T | — | uncertain significance |
| rs2472092208 | 3:101,575,961 | A/C | — | uncertain significance |
| rs771785430 | 3:101,575,972 | A/T | — | uncertain significance |
| rs373241026 | 3:101,576,011 | C/G | — | uncertain significance |
| rs374327466 | 3:101,578,169 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.