rs17347644

This variant is located in the NFKBIZ gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

response to COVID-19 vaccine, COVID-19

Alcalde-Herraiz M et al. “Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank.” Nature Communications 15(1):8739 (2024)

Allele T

OR 0.96

p 1.0e-10

N 315,323

Major Consortium StudyLarge GWAS

European

About NFKBIZ

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

View all NFKBIZ variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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