NGEF
neuronal guanine nucleotide exchange factor
Summary
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in ephrin receptor signaling pathway; regulation of actin cytoskeleton organization; and regulation of synapse organization. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants47 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs778371 | 2:233,743,109 | A/G | downstream gene variant | — |
| rs145959108 | 2:233,744,213 | G/A | — | uncertain significance |
| rs761037996 | 2:233,744,222 | G/T | — | uncertain significance |
| rs201463795 | 2:233,744,270 | G/A | — | uncertain significance |
| rs754143307 | 2:233,744,275 | C/T | — | uncertain significance |
| rs370220062 | 2:233,744,353 | C/T | — | uncertain significance |
| rs544040415 | 2:233,744,375 | C/T | — | uncertain significance |
| rs1016757345 | 2:233,744,384 | T/G | — | uncertain significance |
| rs773087145 | 2:233,745,859 | C/T | — | uncertain significance |
| rs753016089 | 2:233,745,861 | T/A | — | uncertain significance |
| rs141871026 | 2:233,748,147 | G/A | — | uncertain significance |
| rs1026231001 | 2:233,748,795 | C/T | — | uncertain significance |
| rs1448503004 | 2:233,750,012 | T/C | — | uncertain significance |
| rs765456476 | 2:233,750,051 | C/T | — | uncertain significance |
| rs1691749256 | 2:233,752,751 | G/C | — | uncertain significance |
| rs774424502 | 2:233,752,778 | A/G | — | uncertain significance |
| rs1157845742 | 2:233,756,081 | T/C | — | uncertain significance |
| rs377471982 | 2:233,756,165 | G/A | — | uncertain significance |
| rs371214944 | 2:233,756,166 | C/T | — | uncertain significance |
| rs199823442 | 2:233,756,177 | C/G | — | uncertain significance |
| rs61750834 | 2:233,756,191 | C/T | — | benign |
| rs34652626 | 2:233,757,235 | C/T | intron variant | — |
| rs368820247 | 2:233,757,651 | C/T | — | uncertain significance |
| rs765228971 | 2:233,757,696 | C/T | — | uncertain significance |
| rs780444133 | 2:233,759,565 | G/A | — | uncertain significance |
| rs183627770 | 2:233,766,659 | G/A | regulatory region variant | — |
| rs760042186 | 2:233,785,203 | C/T | — | uncertain significance |
| rs868438355 | 2:233,785,217 | T/G | — | uncertain significance |
| rs146798173 | 2:233,785,232 | T/C | — | uncertain significance |
| rs1043271689 | 2:233,785,260 | G/A | — | uncertain significance |
| rs2675952 | 2:233,790,522 | T/A | intron variant | — |
| rs2469555443 | 2:233,791,854 | C/G | — | uncertain significance |
| rs199654749 | 2:233,791,859 | C/T | — | uncertain significance |
| rs2944590 | 2:233,792,207 | G/A | regulatory region variant | — |
| rs2592118 | 2:233,792,425 | C/T | regulatory region variant | — |
| rs778352 | 2:233,804,330 | A/T | intron variant | — |
| rs568015409 | 2:233,808,252 | C/T | — | — |
| rs11678490 | 2:233,830,950 | G/A | regulatory region variant | — |
| rs182107541 | 2:233,839,354 | G/A | — | uncertain significance |
| rs762438390 | 2:233,839,390 | G/A | — | uncertain significance |
| rs1694256137 | 2:233,839,396 | T/C | — | likely benign |
| rs776864089 | 2:233,839,401 | C/T | — | uncertain significance |
| rs143190519 | 2:233,839,402 | G/A | — | uncertain significance |
| rs146081416 | 2:233,839,448 | T/G | — | uncertain significance |
| rs1694259033 | 2:233,839,483 | C/T | — | likely benign |
| rs562152587 | 2:233,860,214 | A/G | — | — |
| rs12471240 | 2:233,864,627 | G/C | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.