NGF

nerve growth factor

Summary

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Known Variants160 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs886045114	1:115,828,571	A/C	—	uncertain significance
rs561107153	1:115,828,711	T/G	—	uncertain significance
rs750539380	1:115,828,730	A/G	—	uncertain significance
rs565497625	1:115,828,736	C/T	—	likely benign
rs1326012011	1:115,828,737	G/T	—	uncertain significance
rs34542615	1:115,828,740	T/C	—	uncertain significance
rs1553234714	1:115,828,745	C/T	—	likely benign
rs1553234715	1:115,828,747	G/A	—	uncertain significance
rs1057524350	1:115,828,752	A/C	—	uncertain significance
rs1432643322	1:115,828,755	C/A	—	uncertain significance
rs11466112	1:115,828,756	G/A	missense variant	pathogenic
rs2101018295	1:115,828,760	G/A	—	likely benign
rs371529651	1:115,828,772	G/A	—	likely benign
rs985498627	1:115,828,779	A/G	—	uncertain significance
rs1653491943	1:115,828,785	A/G	—	uncertain significance
rs112292538	1:115,828,787	C/T	—	likely benign
rs1653492574	1:115,828,804	G/C	—	uncertain significance
rs143157422	1:115,828,808	C/T	—	likely benign
rs774626005	1:115,828,817	A/G	—	likely benign
rs2101018460	1:115,828,842	A/G	—	uncertain significance
rs2101018467	1:115,828,844	G/A	—	likely benign
rs2101018470	1:115,828,845	C/A	—	uncertain significance
rs760753923	1:115,828,855	C/T	—	uncertain significance
rs779744960	1:115,828,856	G/A	—	likely benign
rs1571069395	1:115,828,857	C/T	—	uncertain significance
rs141889164	1:115,828,864	C/T	—	conflicting classifications of pathogenicity
rs532714783	1:115,828,865	G/A	—	conflicting classifications of pathogenicity
rs2525329722	1:115,828,873	G/A	—	uncertain significance
rs758166016	1:115,828,878	C/T	—	uncertain significance
rs1571069427	1:115,828,880	G/A	—	likely benign
rs777582167	1:115,828,887	G/A	—	uncertain significance
rs1557933464	1:115,828,902	T/C	—	uncertain significance
rs375808064	1:115,828,905	T/C	—	uncertain significance
rs139541754	1:115,828,909	A/G	—	uncertain significance
rs745359909	1:115,828,913	A/T	—	uncertain significance
rs1653498654	1:115,828,926	T/A	—	uncertain significance
rs774878867	1:115,828,930	C/T	—	uncertain significance
rs1394210230	1:115,828,931	C/T	—	likely benign
rs748481624	1:115,828,934	T/C	—	likely benign
rs139830389	1:115,828,935	C/G	—	uncertain significance
rs1175374447	1:115,828,937	C/T	—	likely benign
rs886045115	1:115,828,940	C/T	—	conflicting classifications of pathogenicity
rs1571069537	1:115,828,949	C/T	—	likely benign
rs369927492	1:115,828,951	C/T	—	uncertain significance
rs2525330119	1:115,828,961	G/A	—	likely benign
rs149823633	1:115,828,972	C/A	—	uncertain significance
rs765111580	1:115,828,976	G/A	—	likely benign
rs1571069577	1:115,828,978	T/A	—	uncertain significance
rs758273427	1:115,828,989	A/G	—	uncertain significance
rs199511298	1:115,828,996	C/G	—	uncertain significance
rs751386981	1:115,828,997	G/A	—	likely benign
rs369555032	1:115,829,000	G/A	—	likely benign
rs2101018808	1:115,829,005	T/C	—	uncertain significance
rs565841831	1:115,829,015	C/T	—	likely benign
rs746897874	1:115,829,018	G/T	—	uncertain significance
rs772557857	1:115,829,023	C/T	—	uncertain significance
rs778162180	1:115,829,024	G/A	—	likely benign
rs2101018849	1:115,829,028	C/T	—	uncertain significance
rs1421686319	1:115,829,029	T/C	—	uncertain significance
rs372985633	1:115,829,036	G/A	—	likely benign
rs1409051848	1:115,829,045	G/C	—	likely benign
rs1011323001	1:115,829,046	G/A	—	uncertain significance
rs1272434944	1:115,829,056	G/A	—	uncertain significance
rs2101018914	1:115,829,063	C/T	—	likely benign
rs2525330604	1:115,829,066	G/A	—	likely benign
rs376618971	1:115,829,074	T/C	—	uncertain significance
rs867581456	1:115,829,077	T/G	—	uncertain significance
rs2525330638	1:115,829,079	A/G	—	uncertain significance
rs147763877	1:115,829,082	G/C	—	uncertain significance
rs145894043	1:115,829,095	C/T	—	uncertain significance
rs202005277	1:115,829,096	G/A	—	likely benign
rs750030065	1:115,829,099	C/G	—	uncertain significance
rs755580704	1:115,829,101	C/T	—	uncertain significance
rs779678303	1:115,829,102	G/A	—	likely benign
rs150136942	1:115,829,133	C/T	—	likely benign
rs771270154	1:115,829,134	G/T	—	uncertain significance
rs2101019032	1:115,829,137	G/T	—	uncertain significance
rs202060337	1:115,829,141	C/T	—	benign
rs2101019050	1:115,829,142	T/C	—	uncertain significance
rs769893063	1:115,829,153	C/T	—	likely benign
rs775686730	1:115,829,155	G/A	—	likely benign
rs200629339	1:115,829,160	C/T	—	uncertain significance
rs2101019098	1:115,829,164	G/A	—	uncertain significance
rs767272925	1:115,829,169	C/T	—	uncertain significance
rs138175552	1:115,829,170	G/A	—	conflicting classifications of pathogenicity
rs765918245	1:115,829,171	G/A	—	likely benign
rs968846429	1:115,829,175	C/T	—	uncertain significance
rs753382007	1:115,829,176	G/A	—	pathogenic
rs1160629618	1:115,829,177	C/G	—	likely benign
rs11466111	1:115,829,178	T/C	—	likely benign
rs778266438	1:115,829,179	G/A	—	uncertain significance
rs141486298	1:115,829,193	C/T	—	conflicting classifications of pathogenicity
rs780383333	1:115,829,198	G/A	—	likely benign
rs1414433934	1:115,829,201	C/T	—	likely benign
rs11466110	1:115,829,203	C/T	—	likely benign
rs768794852	1:115,829,209	T/C	—	uncertain significance
rs2101019205	1:115,829,212	T/G	—	uncertain significance
rs377253859	1:115,829,214	C/T	—	uncertain significance
rs572066909	1:115,829,215	G/A	—	uncertain significance
rs760350868	1:115,829,216	G/T	—	likely benign

Showing 100 of 160 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.