NMT1
N-myristoyltransferase 1
Summary
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]
Known Variants19 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs77288888 | 17:43,143,662 | A/G | intron variant | — |
| rs6503417 | 17:43,144,218 | T/C | upstream gene variant | — |
| rs4793169 | 17:43,152,877 | T/G | — | — |
| rs56360935 | 17:43,156,135 | A/T | intron variant | — |
| rs7214267 | 17:43,157,709 | G/T | — | — |
| rs1212522731 | 17:43,159,023 | C/T | — | uncertain significance |
| rs2054018267 | 17:43,159,098 | C/T | — | uncertain significance |
| rs1281614790 | 17:43,159,109 | C/A | — | uncertain significance |
| rs868718436 | 17:43,163,951 | G/T | — | uncertain significance |
| rs150418753 | 17:43,174,504 | G/A | — | uncertain significance |
| rs376218058 | 17:43,175,907 | G/A | — | uncertain significance |
| rs12936234 | 17:43,177,951 | T/C | intron variant | — |
| rs750330678 | 17:43,180,320 | C/G | — | uncertain significance |
| rs760138330 | 17:43,180,331 | G/A | — | uncertain significance |
| rs2143523454 | 17:43,180,386 | C/G | — | uncertain significance |
| rs1208099201 | 17:43,180,413 | C/T | — | uncertain significance |
| rs148483868 | 17:43,180,418 | G/A | — | uncertain significance |
| rs773052955 | 17:43,181,117 | C/T | — | uncertain significance |
| rs774301899 | 17:43,182,299 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.