NPY1R
neuropeptide Y receptor Y1
Summary
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Known Variants22 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4057797 | 4:164,245,053 | T/G | — | — |
| rs9764 | 4:164,245,405 | T/C | 3 prime UTR variant | — |
| rs4552421 | 4:164,245,663 | A/G | 3 prime UTR variant | — |
| rs10033119 | 4:164,245,854 | A/C | — | — |
| rs5578 | 4:164,246,489 | T/G | — | benign |
| rs138527737 | 4:164,246,610 | A/G | — | uncertain significance |
| rs762997984 | 4:164,246,676 | A/G | — | uncertain significance |
| rs764292344 | 4:164,246,720 | T/C | — | uncertain significance |
| rs2477588087 | 4:164,246,855 | T/C | — | uncertain significance |
| rs150716145 | 4:164,246,858 | T/C | — | likely benign |
| rs193054357 | 4:164,246,877 | T/C | — | uncertain significance |
| rs201792729 | 4:164,246,901 | G/A | — | uncertain significance |
| rs2477589002 | 4:164,247,049 | A/G | — | uncertain significance |
| rs1734595835 | 4:164,247,123 | T/C | — | uncertain significance |
| rs757037175 | 4:164,247,135 | G/A | — | uncertain significance |
| rs1734600093 | 4:164,247,249 | C/T | — | uncertain significance |
| rs1465197647 | 4:164,247,398 | C/G | — | uncertain significance |
| rs2477591359 | 4:164,247,471 | A/G | — | uncertain significance |
| rs746038594 | 4:164,247,553 | T/A | — | uncertain significance |
| rs147899436 | 4:164,247,579 | A/G | — | uncertain significance |
| rs28436846 | 4:164,248,802 | T/C | intron variant | — |
| rs6837793 | 4:164,256,735 | A/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.