NRP1

neuropilin 1

Summary

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]

Known Variants149 total

rsidPosition (GRCh37)AllelesClassClinVar
rs18794557610:33,466,069A/Cdownstream gene variant—
rs1008010:33,467,108G/Aregulatory region variant—
rs18777408010:33,468,998C/T—likely benign
rs126577203910:33,469,014G/A—uncertain significance
rs76922614910:33,469,080T/C—uncertain significance
rs77726139610:33,469,087C/G—uncertain significance
rs137704729710:33,469,131G/T—uncertain significance
rs20033087110:33,469,144C/T—uncertain significance
rs14643191110:33,469,145G/T—benign
rs77863023010:33,469,147C/A—uncertain significance
rs104880410:33,469,181A/G—benign
rs14484532210:33,469,205G/C—uncertain significance
rs19264431910:33,469,214T/C—likely benign
rs249170380010:33,469,254T/C—uncertain significance
rs54002229410:33,469,258C/T—uncertain significance
rs93609960010:33,469,274T/A—uncertain significance
rs15035178910:33,469,276C/T—likely benign
rs222993610:33,469,286C/T—benign
rs19968976910:33,469,296A/G—likely benign
rs249171460610:33,471,632C/T—uncertain significance
rs249171465110:33,471,635C/G—uncertain significance
rs20157027810:33,471,637A/G—uncertain significance
rs52892174510:33,474,553T/C—likely benign
rs13826177810:33,474,632G/A—likely benign
rs14385825810:33,474,638G/A—likely benign
rs6176043210:33,474,644G/A—benign
rs77510840610:33,474,652C/G—uncertain significance
rs183599665310:33,475,162A/G—uncertain significance
rs92414928010:33,475,180G/A—uncertain significance
rs249173728510:33,475,182C/T—uncertain significance
rs78002765310:33,475,217C/T—uncertain significance
rs55487287610:33,475,257C/T—uncertain significance
rs222863810:33,475,282C/Tmissense variantbenign
rs37605316510:33,475,283G/T—uncertain significance
rs75797712910:33,475,287G/A—uncertain significance
rs15089126110:33,475,359C/A—uncertain significance
rs14406341210:33,475,391T/C—likely benign
rs250614810:33,477,430G/Cintron variant—
rs75260281510:33,481,204G/A—likely benign
rs14316608210:33,481,231C/T—likely benign
rs54573729210:33,481,333A/G—likely benign
rs37172940310:33,481,349T/G—uncertain significance
rs18934598510:33,483,131C/Gregulatory region variant—
rs247472410:33,484,577C/A——
rs20128899410:33,486,604G/A—uncertain significance
rs183688428110:33,486,608G/A—uncertain significance
rs1082720810:33,486,667A/C——
rs224738310:33,489,052G/C——
rs247472010:33,491,186T/A——
rs14891333510:33,491,868G/A—likely benign
rs36781366410:33,491,883C/T—likely benign
rs14804149110:33,491,886C/T—likely benign
rs14163335410:33,491,894C/T—uncertain significance
rs14705509310:33,491,895G/A—likely benign
rs75473228010:33,491,923G/A—uncertain significance
rs20164039810:33,495,183C/T—likely benign
rs6176041910:33,496,521G/A—benign
rs56995228510:33,496,539G/C—likely benign
rs77816025610:33,496,542C/T—uncertain significance
rs37169157010:33,496,555T/C—likely benign
rs116313250110:33,496,575T/G—uncertain significance
rs222863710:33,496,576G/C—benign
rs14312468210:33,496,583G/A—uncertain significance
rs77974579010:33,496,605G/A—uncertain significance
rs76985920110:33,496,622T/A—uncertain significance
rs76282644210:33,496,633G/A—uncertain significance
rs15062588910:33,502,317C/T—likely benign
rs133001908610:33,502,319C/T—uncertain significance
rs76365708510:33,502,324C/G—uncertain significance
rs75810022810:33,502,356C/T—likely benign
rs11752505710:33,502,357G/A—benign
rs120545781310:33,502,361C/T—uncertain significance
rs14943890210:33,502,362G/A—likely benign
rs76998269310:33,502,376C/T—uncertain significance
rs14587777310:33,502,377G/A—likely benign
rs76356375510:33,502,379T/C—uncertain significance
rs55489298910:33,502,411C/T—uncertain significance
rs37106439810:33,502,431G/T—likely benign
rs74957546710:33,502,445C/T—uncertain significance
rs55671231910:33,502,461C/G—benign
rs18243702510:33,502,469T/C—uncertain significance
rs104293411310:33,502,483T/C—uncertain significance
rs76281561510:33,502,503G/A—likely benign
rs75156352710:33,502,525C/T—uncertain significance
rs14595453210:33,502,633G/A—likely benign
rs250615510:33,503,179C/T——
rs222993510:33,510,663G/Asynonymous variantbenign
rs14205506010:33,510,666T/C—likely benign
rs75204380010:33,510,715C/T—uncertain significance
rs222993410:33,510,768G/A—benign
rs13827679810:33,511,858G/Aintron variant—
rs19967353910:33,515,090A/G—likely benign
rs37055143210:33,515,103C/T—uncertain significance
rs76799960710:33,515,104G/A—likely benign
rs14996620610:33,515,123T/A—uncertain significance
rs74648458210:33,515,137A/G—likely benign
rs74814295510:33,515,158T/G—uncertain significance
rs77469289110:33,515,170G/A—likely benign
rs14511626910:33,515,188C/T—likely benign
rs14212108110:33,515,189G/A—uncertain significance

Showing 100 of 149 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.