NRXN2

neurexin 2

Summary

This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

Known Variants204 total

rsidPosition (GRCh37)AllelesClassClinVar
rs159142215411:64,374,742T/G—not provided
rs75550177011:64,374,820G/A—uncertain significance
rs14938659611:64,374,822T/C—uncertain significance
rs14474224811:64,374,875C/T—benign
rs53712045711:64,374,946C/T—uncertain significance
rs37716431611:64,374,960C/A—likely benign
rs249559824411:64,374,984T/C—likely benign
rs94500784311:64,374,994C/G—uncertain significance
rs95870959711:64,374,996G/A—uncertain significance
rs122732489811:64,375,030G/T—uncertain significance
rs249560020711:64,375,156A/G—likely benign
rs77538055811:64,375,182C/T—uncertain significance
rs79704580111:64,375,185T/A—uncertain significance
rs249560070411:64,375,206G/C—uncertain significance
rs122742478411:64,375,212G/T—uncertain significance
rs74939843311:64,375,288G/A—uncertain significance
rs123029620211:64,375,352G/T—uncertain significance
rs75022243811:64,375,361G/C—uncertain significance
rs148245511011:64,375,367C/A—uncertain significance
rs7157986911:64,375,370G/A—uncertain significance
rs11162545111:64,375,392G/T—uncertain significance
rs203994581911:64,375,416G/A—uncertain significance
rs131934805011:64,375,548T/C—uncertain significance
rs7157989911:64,375,757C/T—benign
rs56762756611:64,387,769T/C—uncertain significance
rs37664259311:64,387,803G/A—likely benign
rs227731111:64,387,932G/A—benign
rs75859630411:64,390,236T/C—uncertain significance
rs119196524211:64,390,256C/T—uncertain significance
rs249570925711:64,390,302T/C—uncertain significance
rs20114603111:64,390,340G/A—uncertain significance
rs37081233111:64,390,345C/A—uncertain significance
rs55272851511:64,390,352C/T—uncertain significance
rs18841109011:64,390,363G/A—likely benign
rs37471116611:64,390,371C/T—uncertain significance
rs74535905411:64,390,378C/G—likely benign
rs37243802111:64,390,422C/T—uncertain significance
rs37563964211:64,390,433G/A—uncertain significance
rs76631316711:64,390,500G/A—uncertain significance
rs74965677411:64,390,515T/A—uncertain significance
rs58778040911:64,390,547C/A—uncertain significance
rs14604733011:64,392,244C/Tintron variant—
rs11794979611:64,397,491T/Cregulatory region variant—
rs37655294711:64,397,865G/A—benign
rs7349214911:64,397,980G/A—likely benign
rs6188440611:64,402,695T/C—benign
rs14836818711:64,402,743G/T—likely benign
rs249581504011:64,402,772C/T—uncertain significance
rs75904774211:64,402,803G/A—likely benign
rs15039044011:64,402,918G/A—uncertain significance
rs37305942611:64,402,922C/T—uncertain significance
rs156526694011:64,410,182G/A—uncertain significance
rs37155411311:64,415,690C/T—uncertain significance
rs79704580011:64,415,691G/A—likely benign
rs18739724511:64,415,726G/A—uncertain significance
rs382507411:64,415,767G/A—benign
rs5973900611:64,415,903C/T—benign
rs7292519711:64,416,031C/A—benign
rs141343650911:64,416,233T/C—uncertain significance
rs76554285311:64,416,235C/T—uncertain significance
rs99022959111:64,416,245C/A—uncertain significance
rs37118095711:64,416,261T/C—uncertain significance
rs249594215311:64,416,272C/T—uncertain significance
rs13926419211:64,416,276G/C—benign
rs77703356911:64,416,313C/T—uncertain significance
rs14847365311:64,416,356T/C—likely benign
rs75612741911:64,417,968G/A—uncertain significance
rs36973781511:64,417,970G/A—uncertain significance
rs37748953111:64,417,992C/T—uncertain significance
rs55545611:64,418,259T/C—benign
rs228533911:64,418,305G/A—benign
rs14490680911:64,418,721C/T—benign
rs249596264111:64,418,740C/T—uncertain significance
rs18406800011:64,418,762G/A—likely benign
rs52633811:64,418,900G/A—benign
rs37429993911:64,418,907C/T—uncertain significance
rs249596433511:64,418,937T/C—uncertain significance
rs20151115811:64,418,948A/C—likely benign
rs76546535211:64,418,968T/C—uncertain significance
rs20002402011:64,418,989C/T—likely benign
rs74771596011:64,419,039C/T—uncertain significance
rs125608138011:64,419,040G/A—uncertain significance
rs143915552811:64,419,060G/A—uncertain significance
rs79704579911:64,419,116G/A—benign
rs50257111:64,419,217T/G—benign
rs50256711:64,419,218T/C—benign
rs249597003811:64,419,528C/G—uncertain significance
rs7157985711:64,419,580A/G—uncertain significance
rs78156367511:64,419,587T/C—uncertain significance
rs249597062811:64,419,596T/C—uncertain significance
rs20023153211:64,419,602G/A—uncertain significance
rs249597086011:64,419,624T/G—uncertain significance
rs53407311:64,421,052C/T—benign
rs14899675411:64,421,175G/A—benign
rs56169050111:64,421,197G/T—uncertain significance
rs5763399211:64,424,967C/Aintron variant—
rs115262611:64,427,673G/A—benign
rs76374502811:64,427,849G/A—uncertain significance
rs213548536211:64,427,864A/T—uncertain significance
rs13829175811:64,427,912T/A—uncertain significance

Showing 100 of 204 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.