NRXN2

neurexin 2

Summary

This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

Known Variants204 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1591422154	11:64,374,742	T/G	—	not provided
rs755501770	11:64,374,820	G/A	—	uncertain significance
rs149386596	11:64,374,822	T/C	—	uncertain significance
rs144742248	11:64,374,875	C/T	—	benign
rs537120457	11:64,374,946	C/T	—	uncertain significance
rs377164316	11:64,374,960	C/A	—	likely benign
rs2495598244	11:64,374,984	T/C	—	likely benign
rs945007843	11:64,374,994	C/G	—	uncertain significance
rs958709597	11:64,374,996	G/A	—	uncertain significance
rs1227324898	11:64,375,030	G/T	—	uncertain significance
rs2495600207	11:64,375,156	A/G	—	likely benign
rs775380558	11:64,375,182	C/T	—	uncertain significance
rs797045801	11:64,375,185	T/A	—	uncertain significance
rs2495600704	11:64,375,206	G/C	—	uncertain significance
rs1227424784	11:64,375,212	G/T	—	uncertain significance
rs749398433	11:64,375,288	G/A	—	uncertain significance
rs1230296202	11:64,375,352	G/T	—	uncertain significance
rs750222438	11:64,375,361	G/C	—	uncertain significance
rs1482455110	11:64,375,367	C/A	—	uncertain significance
rs71579869	11:64,375,370	G/A	—	uncertain significance
rs111625451	11:64,375,392	G/T	—	uncertain significance
rs2039945819	11:64,375,416	G/A	—	uncertain significance
rs1319348050	11:64,375,548	T/C	—	uncertain significance
rs71579899	11:64,375,757	C/T	—	benign
rs567627566	11:64,387,769	T/C	—	uncertain significance
rs376642593	11:64,387,803	G/A	—	likely benign
rs2277311	11:64,387,932	G/A	—	benign
rs758596304	11:64,390,236	T/C	—	uncertain significance
rs1191965242	11:64,390,256	C/T	—	uncertain significance
rs2495709257	11:64,390,302	T/C	—	uncertain significance
rs201146031	11:64,390,340	G/A	—	uncertain significance
rs370812331	11:64,390,345	C/A	—	uncertain significance
rs552728515	11:64,390,352	C/T	—	uncertain significance
rs188411090	11:64,390,363	G/A	—	likely benign
rs374711166	11:64,390,371	C/T	—	uncertain significance
rs745359054	11:64,390,378	C/G	—	likely benign
rs372438021	11:64,390,422	C/T	—	uncertain significance
rs375639642	11:64,390,433	G/A	—	uncertain significance
rs766313167	11:64,390,500	G/A	—	uncertain significance
rs749656774	11:64,390,515	T/A	—	uncertain significance
rs587780409	11:64,390,547	C/A	—	uncertain significance
rs146047330	11:64,392,244	C/T	intron variant	—
rs117949796	11:64,397,491	T/C	regulatory region variant	—
rs376552947	11:64,397,865	G/A	—	benign
rs73492149	11:64,397,980	G/A	—	likely benign
rs61884406	11:64,402,695	T/C	—	benign
rs148368187	11:64,402,743	G/T	—	likely benign
rs2495815040	11:64,402,772	C/T	—	uncertain significance
rs759047742	11:64,402,803	G/A	—	likely benign
rs150390440	11:64,402,918	G/A	—	uncertain significance
rs373059426	11:64,402,922	C/T	—	uncertain significance
rs1565266940	11:64,410,182	G/A	—	uncertain significance
rs371554113	11:64,415,690	C/T	—	uncertain significance
rs797045800	11:64,415,691	G/A	—	likely benign
rs187397245	11:64,415,726	G/A	—	uncertain significance
rs3825074	11:64,415,767	G/A	—	benign
rs59739006	11:64,415,903	C/T	—	benign
rs72925197	11:64,416,031	C/A	—	benign
rs1413436509	11:64,416,233	T/C	—	uncertain significance
rs765542853	11:64,416,235	C/T	—	uncertain significance
rs990229591	11:64,416,245	C/A	—	uncertain significance
rs371180957	11:64,416,261	T/C	—	uncertain significance
rs2495942153	11:64,416,272	C/T	—	uncertain significance
rs139264192	11:64,416,276	G/C	—	benign
rs777033569	11:64,416,313	C/T	—	uncertain significance
rs148473653	11:64,416,356	T/C	—	likely benign
rs756127419	11:64,417,968	G/A	—	uncertain significance
rs369737815	11:64,417,970	G/A	—	uncertain significance
rs377489531	11:64,417,992	C/T	—	uncertain significance
rs555456	11:64,418,259	T/C	—	benign
rs2285339	11:64,418,305	G/A	—	benign
rs144906809	11:64,418,721	C/T	—	benign
rs2495962641	11:64,418,740	C/T	—	uncertain significance
rs184068000	11:64,418,762	G/A	—	likely benign
rs526338	11:64,418,900	G/A	—	benign
rs374299939	11:64,418,907	C/T	—	uncertain significance
rs2495964335	11:64,418,937	T/C	—	uncertain significance
rs201511158	11:64,418,948	A/C	—	likely benign
rs765465352	11:64,418,968	T/C	—	uncertain significance
rs200024020	11:64,418,989	C/T	—	likely benign
rs747715960	11:64,419,039	C/T	—	uncertain significance
rs1256081380	11:64,419,040	G/A	—	uncertain significance
rs1439155528	11:64,419,060	G/A	—	uncertain significance
rs797045799	11:64,419,116	G/A	—	benign
rs502571	11:64,419,217	T/G	—	benign
rs502567	11:64,419,218	T/C	—	benign
rs2495970038	11:64,419,528	C/G	—	uncertain significance
rs71579857	11:64,419,580	A/G	—	uncertain significance
rs781563675	11:64,419,587	T/C	—	uncertain significance
rs2495970628	11:64,419,596	T/C	—	uncertain significance
rs200231532	11:64,419,602	G/A	—	uncertain significance
rs2495970860	11:64,419,624	T/G	—	uncertain significance
rs534073	11:64,421,052	C/T	—	benign
rs148996754	11:64,421,175	G/A	—	benign
rs561690501	11:64,421,197	G/T	—	uncertain significance
rs57633992	11:64,424,967	C/A	intron variant	—
rs1152626	11:64,427,673	G/A	—	benign
rs763745028	11:64,427,849	G/A	—	uncertain significance
rs2135485362	11:64,427,864	A/T	—	uncertain significance
rs138291758	11:64,427,912	T/A	—	uncertain significance

Showing 100 of 204 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.