NSMCE1

NSE1 component of SMC5/6 complex

Summary

Enables protein dimerization activity and ubiquitin protein ligase activity. Involved in DNA damage response. Located in nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants16 total

rsidPosition (GRCh37)AllelesClassClinVar
rs18111700516:27,236,495G/Cuncertain significance
rs77469744616:27,237,076C/Tuncertain significance
rs126579797716:27,237,138C/Guncertain significance
rs20097023716:27,238,081G/Auncertain significance
rs75815538916:27,238,093G/Auncertain significance
rs208370061216:27,238,094T/Cuncertain significance
rs56272771716:27,238,099C/Tuncertain significance
rs37617870316:27,238,129C/Tuncertain significance
rs321144216:27,244,363G/Cuncertain significance
rs54926827216:27,245,565T/Clikely benign
rs3493998416:27,245,712C/A
rs76679142016:27,246,530G/Auncertain significance
rs76957812516:27,268,864C/Tuncertain significance
rs88704363716:27,268,876T/Cuncertain significance
rs77086548816:27,268,884C/Tuncertain significance
rs994055516:27,270,607C/Tintron variant

Gene information from NCBI Gene. Variant classifications from ClinVar.