NXN

nucleoredoxin

Summary

This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]

Known Variants187 total

rsidPosition (GRCh37)AllelesClassClinVar
rs247469517:704,017A/G—benign
rs65537717:704,042T/G—benign
rs77905001717:704,187C/T—likely benign
rs77268595117:704,198C/T—likely benign
rs5634368117:704,201C/T—benign
rs130750653317:704,240C/G—uncertain significance
rs254469414717:704,241T/C—uncertain significance
rs191117104917:704,246G/A—likely benign
rs75581113317:704,264C/G—uncertain significance
rs57051354817:704,267C/T—likely benign
rs53209888217:704,279G/A—likely benign
rs36988794317:704,312G/A—likely benign
rs14868483217:704,323C/A—uncertain significance
rs254469441417:704,335G/C—uncertain significance
rs77401220717:704,342G/A—likely benign
rs76066053217:704,380G/A—likely benign
rs57071017:704,480C/A—benign
rs7397553317:704,500G/T—benign
rs59897417:706,862G/C—benign
rs37418876717:706,913C/T—likely benign
rs11528288917:706,914G/A—benign
rs191132652217:706,915C/T—likely benign
rs37109154617:706,927C/T—uncertain significance
rs6173177017:706,933C/T—benign
rs254469806617:706,957C/T—uncertain significance
rs55134723617:706,997C/T—likely benign
rs37470560117:707,002G/C—uncertain significance
rs36880770317:707,012C/T—likely benign
rs37034703417:707,021C/T—likely benign
rs55012879517:707,022T/A—uncertain significance
rs6173177117:707,024G/A—likely benign
rs76766896317:707,032C/T—uncertain significance
rs20090485217:707,033G/A—likely benign
rs36805051317:707,060G/A—likely benign
rs7571927417:707,062G/A—benign
rs19954613217:707,064G/T—likely benign
rs7281027417:707,152G/A—benign
rs61054217:707,174C/G—benign
rs229547717:708,223A/G—benign
rs18344214017:708,264G/C—benign
rs53883766817:708,294C/T—likely benign
rs18819592417:708,295G/A—likely benign
rs13912493917:708,321G/A—likely benign
rs57551804717:708,336G/A—likely benign
rs254470056917:708,338T/C—uncertain significance
rs7691630517:708,345C/T—benign
rs14644475417:708,346G/A—likely benign
rs75220458617:708,348G/A—likely benign
rs37409306517:708,350C/T—uncertain significance
rs36802509417:708,357G/A—likely benign
rs37259103717:708,359C/T—uncertain significance
rs134004494917:708,360G/C—likely benign
rs37413946017:708,374C/G—uncertain significance
rs14315142517:708,375G/C—likely benign
rs76339810217:708,401G/A—uncertain significance
rs14547671417:708,411G/A—likely benign
rs77740667217:708,414G/A—likely benign
rs77190976817:708,426C/T—likely benign
rs74721937417:708,432C/A—likely benign
rs14384096117:708,441C/T—likely benign
rs118607037117:708,449C/A—uncertain significance
rs37264730217:708,459C/G—likely benign
rs97603946717:708,501G/C—likely benign
rs36896543517:708,503G/T—likely benign
rs229547817:708,531C/T—benign
rs7475076617:708,568G/A—benign
rs7859848617:722,478G/A—benign
rs5860878017:722,619G/A—benign
rs5797194317:722,637G/C—benign
rs36966009217:722,659C/G—likely benign
rs76483934217:722,660C/T—likely benign
rs14883479917:722,672C/T—likely benign
rs76728369017:722,673G/A—uncertain significance
rs191268730917:722,682G/A—pathogenic
rs7281028617:722,689G/A—likely benign
rs77790267217:722,696C/T—uncertain significance
rs20079221117:722,697G/A—uncertain significance
rs77950944117:722,706G/A—uncertain significance
rs131256347217:722,707C/T—likely benign
rs77277364517:722,711C/T—uncertain significance
rs37643057817:722,715G/A—uncertain significance
rs37390267017:722,725C/T—benign
rs191269384317:722,727T/C—uncertain significance
rs20142471417:722,737G/A—likely benign
rs20053338417:722,740G/A—likely benign
rs130281323217:722,747G/A—uncertain significance
rs14248914117:722,765T/A—uncertain significance
rs20013602217:722,774G/A—uncertain significance
rs53215084017:722,782C/T—likely benign
rs20106108717:722,801C/T—likely benign
rs36931589017:722,802G/C—likely benign
rs141977537917:722,803T/C—likely benign
rs246725317:723,034A/G—benign
rs65472817:725,356T/A—benign
rs50377917:725,433C/T—benign
rs1187014817:725,478T/C—benign
rs92322806017:725,577C/A—likely benign
rs37414763617:725,581T/G—likely benign
rs57269762017:725,590G/A—likely benign
rs37029635817:725,610C/T—uncertain significance

Showing 100 of 187 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.