OLIG2
oligodendrocyte transcription factor 2
Summary
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6517135 | 21:34,397,571 | T/C | regulatory region variant | — |
| rs1005573 | 21:34,398,716 | C/G | — | — |
| rs745823267 | 21:34,399,223 | A/C | — | uncertain significance |
| rs2517337756 | 21:34,399,309 | T/C | — | uncertain significance |
| rs762178 | 21:34,399,401 | A/G | synonymous variant | — |
| rs775931016 | 21:34,399,502 | T/G | — | uncertain significance |
| rs1270614322 | 21:34,399,519 | G/A | — | uncertain significance |
| rs766171391 | 21:34,399,569 | G/T | — | uncertain significance |
| rs1257309392 | 21:34,399,769 | C/G | — | uncertain significance |
| rs955089492 | 21:34,399,840 | C/T | — | uncertain significance |
| rs1387063879 | 21:34,399,851 | A/G | — | likely benign |
| rs1233235355 | 21:34,399,942 | C/T | — | uncertain significance |
| rs2517338996 | 21:34,400,002 | G/A | — | uncertain significance |
| rs986394825 | 21:34,400,038 | G/T | — | uncertain significance |
| rs2517339224 | 21:34,400,111 | G/C | — | uncertain significance |
| rs1059004 | 21:34,400,463 | C/A | 3 prime UTR variant | — |
| rs6517137 | 21:34,400,779 | T/C | 3 prime UTR variant | — |
| rs9653711 | 21:34,401,949 | G/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.