rs1005573
This variant is located in the OLIG2 gene.
▶Research that mentions this SNP (1)
▶Positive association between OLIG2 and schizophrenia in the Chinese Han populationAssociationN=617Ke Huang et al.(2008)· Human Genetics
Case-control association study of three OLIG2 variants in 329 Chinese Han schizophrenia patients and 288 controls. SNP rs762178 showed significant association with schizophrenia (P=0.015 after Bonferroni correction, OR=1.73, 95% CI: 1.18-2.55), and the A-T haplotype formed by rs762178 and rs1059004 was also significant (P=0.009). Results suggest OLIG2 variants confer schizophrenia susceptibility in the Chinese population.
About OLIG2
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
View all OLIG2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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