PDCD1LG2

programmed cell death 1 ligand 2

Summary

Involved in negative regulation of activated T cell proliferation; negative regulation of interleukin-10 production; and negative regulation of type II interferon production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants28 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs141265736	9:5,508,987	G/A	—	—
rs185199691	9:5,509,196	G/T	upstream gene variant	—
rs577214809	9:5,522,173	G/C	—	—
rs1037381642	9:5,522,598	G/C	—	uncertain significance
rs779657826	9:5,522,599	C/T	—	uncertain significance
rs189772690	9:5,528,045	G/T	intron variant	—
rs77316406	9:5,528,923	T/A	intron variant	—
rs555131399	9:5,532,785	T/C	—	—
rs373050561	9:5,534,852	A/C	—	likely benign
rs948916084	9:5,534,853	T/C	—	uncertain significance
rs2129794179	9:5,534,900	G/A	—	uncertain significance
rs376982371	9:5,534,960	C/G	—	uncertain significance
rs57753863	9:5,543,534	G/C	intron variant	—
rs145634667	9:5,545,911	G/A	intron variant	—
rs1208687109	9:5,549,351	A/G	—	uncertain significance
rs2129874104	9:5,549,363	C/G	—	uncertain significance
rs535770193	9:5,549,413	G/A	—	uncertain significance
rs768123989	9:5,549,415	T/A	—	uncertain significance
rs774062534	9:5,549,421	C/G	—	uncertain significance
rs774533109	9:5,549,527	C/T	—	uncertain significance
rs138254251	9:5,549,568	G/A	—	likely benign
rs770915970	9:5,557,629	C/T	—	uncertain significance
rs7854413	9:5,557,708	T/C	missense variant	—
rs139007200	9:5,557,726	T/A	—	uncertain significance
rs1816599755	9:5,563,171	A/C	—	uncertain significance
rs142289553	9:5,569,954	A/G	—	uncertain significance
rs73641643	9:5,570,944	C/T	3 prime UTR variant	—
rs141281211	9:5,571,417	C/G	downstream gene variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.