rs7854413
This is a protein-altering variant in the PDCD1LG2 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
programmed cell death 1 ligand 2 amount
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele T
OR 0.25
p 7.0e-27
N 10,708
Large GWAS
European
Allele T
OR —
β 0.290
p 5.0e-12
N 3,301
Large GWAS
European
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele T
OR 0.31
p 4.0e-22
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
blood protein amount
Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele C
OR 0.32
p 2.0e-19
N 5,357
Large GWAS
European
About PDCD1LG2
Involved in negative regulation of activated T cell proliferation; negative regulation of interleukin-10 production; and negative regulation of type II interferon production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Jul 2025]
View all PDCD1LG2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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