PDE3B
phosphodiesterase 3B
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of lipid catabolic process; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants89 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs746745737 | 11:14,665,656 | G/T | — | uncertain significance |
| rs1853284020 | 11:14,665,673 | G/A | — | uncertain significance |
| rs373348482 | 11:14,665,688 | C/A | — | uncertain significance |
| rs1336260511 | 11:14,665,695 | A/G | — | uncertain significance |
| rs756967590 | 11:14,665,698 | G/A | — | uncertain significance |
| rs781061945 | 11:14,665,709 | G/C | — | uncertain significance |
| rs769248459 | 11:14,665,754 | C/T | — | uncertain significance |
| rs536799125 | 11:14,665,761 | T/G | — | uncertain significance |
| rs757601741 | 11:14,665,850 | C/G | — | uncertain significance |
| rs534967735 | 11:14,665,851 | G/C | — | uncertain significance |
| rs755210946 | 11:14,665,872 | C/T | — | uncertain significance |
| rs1310022707 | 11:14,665,893 | C/T | — | uncertain significance |
| rs751966148 | 11:14,665,978 | G/C | — | uncertain significance |
| rs543177469 | 11:14,665,982 | C/T | — | uncertain significance |
| rs2494129287 | 11:14,666,013 | T/G | — | uncertain significance |
| rs376962336 | 11:14,666,030 | A/G | — | uncertain significance |
| rs1377015091 | 11:14,666,073 | C/G | — | uncertain significance |
| rs1590023524 | 11:14,666,097 | C/T | — | uncertain significance |
| rs371863566 | 11:14,666,186 | C/A | — | uncertain significance |
| rs534858355 | 11:14,666,229 | G/C | — | uncertain significance |
| rs756035375 | 11:14,666,259 | C/G | — | uncertain significance |
| rs752589632 | 11:14,666,270 | C/T | — | uncertain significance |
| rs373602584 | 11:14,666,330 | C/G | — | uncertain significance |
| rs776413938 | 11:14,666,361 | T/C | — | uncertain significance |
| rs766103990 | 11:14,666,369 | G/T | — | likely benign |
| rs137936744 | 11:14,666,386 | T/G | — | benign |
| rs901878445 | 11:14,666,423 | C/G | — | uncertain significance |
| rs776472791 | 11:14,666,436 | C/T | — | uncertain significance |
| rs2494133200 | 11:14,666,444 | C/T | — | uncertain significance |
| rs1354031309 | 11:14,666,544 | A/G | — | uncertain significance |
| rs10832289 | 11:14,669,496 | A/T | upstream gene variant | — |
| rs7127312 | 11:14,683,045 | T/A | — | — |
| rs61883634 | 11:14,683,048 | G/A | intron variant | — |
| rs558528882 | 11:14,708,619 | G/A | — | — |
| rs117720468 | 11:14,731,666 | G/C | intron variant | — |
| rs187443664 | 11:14,768,892 | T/G | intron variant | — |
| rs1007392 | 11:14,774,591 | A/G | intron variant | — |
| rs11023332 | 11:14,784,110 | G/C | intron variant | — |
| rs188480917 | 11:14,785,870 | C/G | intron variant | — |
| rs10832300 | 11:14,788,963 | A/G | intron variant | — |
| rs539505257 | 11:14,802,481 | G/T | — | — |
| rs185693786 | 11:14,804,296 | G/A | intron variant | — |
| rs913474010 | 11:14,808,032 | G/C | — | uncertain significance |
| rs749703705 | 11:14,808,089 | C/G | — | uncertain significance |
| rs1417731743 | 11:14,808,095 | G/C | — | uncertain significance |
| rs775728786 | 11:14,808,114 | G/C | — | uncertain significance |
| rs764480858 | 11:14,808,121 | T/C | — | uncertain significance |
| rs748242339 | 11:14,810,746 | G/C | — | uncertain significance |
| rs534042887 | 11:14,818,258 | G/T | — | — |
| rs61885960 | 11:14,819,828 | T/C | — | — |
| rs532836473 | 11:14,822,853 | G/A | — | — |
| rs146783540 | 11:14,825,560 | G/A | — | likely benign |
| rs761839584 | 11:14,825,593 | G/T | — | uncertain significance |
| rs76778262 | 11:14,837,253 | A/C | intron variant | — |
| rs1370463188 | 11:14,839,782 | A/G | — | likely benign |
| rs1272017772 | 11:14,839,810 | T/A | — | uncertain significance |
| rs749259214 | 11:14,839,891 | C/T | — | uncertain significance |
| rs369088329 | 11:14,839,898 | T/G | — | uncertain significance |
| rs78731290 | 11:14,840,696 | T/C | — | likely benign |
| rs147001086 | 11:14,852,254 | A/C | — | likely benign |
| rs761623026 | 11:14,852,268 | A/C | — | uncertain significance |
| rs758278089 | 11:14,852,280 | A/G | — | uncertain significance |
| rs114395954 | 11:14,852,401 | T/C | — | benign |
| rs2494134943 | 11:14,854,362 | G/C | — | uncertain significance |
| rs1011649 | 11:14,856,108 | C/A | intron variant | — |
| rs2494139992 | 11:14,856,564 | C/A | — | uncertain significance |
| rs1322300158 | 11:14,865,392 | C/A | — | uncertain significance |
| rs150090666 | 11:14,865,399 | C/T | stop gained | — |
| rs772001660 | 11:14,865,419 | G/A | — | likely benign |
| rs1350442610 | 11:14,865,426 | T/C | — | uncertain significance |
| rs973782883 | 11:14,865,430 | C/G | — | uncertain significance |
| rs2494157583 | 11:14,865,490 | C/G | — | uncertain significance |
| rs10832310 | 11:14,878,442 | C/T | — | — |
| rs142156684 | 11:14,880,624 | T/C | — | benign |
| rs781661071 | 11:14,880,662 | G/A | — | uncertain significance |
| rs111436102 | 11:14,880,729 | T/C | — | benign |
| rs113344545 | 11:14,880,801 | T/C | — | benign |
| rs201501563 | 11:14,882,470 | C/T | — | — |
| rs113803419 | 11:14,882,756 | T/C | — | benign |
| rs540244822 | 11:14,882,884 | A/G | — | uncertain significance |
| rs143026894 | 11:14,889,208 | G/A | — | benign |
| rs782206472 | 11:14,889,264 | A/C | — | uncertain significance |
| rs143928343 | 11:14,889,271 | G/A | — | uncertain significance |
| rs1304702113 | 11:14,889,283 | A/G | — | uncertain significance |
| rs184319937 | 11:14,891,014 | A/G | — | benign |
| rs201545023 | 11:14,891,034 | G/A | — | likely benign |
| rs368611800 | 11:14,891,121 | A/G | — | uncertain significance |
| rs61736639 | 11:14,891,141 | G/C | — | benign |
| rs1848110383 | 11:14,891,177 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.