PDLIM4
PDZ and LIM domain 4
Summary
Enables alpha-actinin binding activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in actin cytoskeleton organization. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Part of filamentous actin. Implicated in osteoporosis. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants19 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs453602 | 5:131,587,064 | C/T | — | risk factor |
| rs112537099 | 5:131,591,725 | C/T | — | — |
| rs772364788 | 5:131,593,438 | C/T | — | uncertain significance |
| rs2531900676 | 5:131,593,488 | C/T | — | uncertain significance |
| rs7735891 | 5:131,597,005 | C/T | intron variant | — |
| rs374632066 | 5:131,598,457 | T/C | — | likely benign |
| rs55633655 | 5:131,598,756 | T/G | — | — |
| rs7736102 | 5:131,604,257 | G/A | regulatory region variant | — |
| rs6897575 | 5:131,604,535 | C/T | regulatory region variant | — |
| rs2531930192 | 5:131,606,618 | C/G | — | uncertain significance |
| rs1386092214 | 5:131,606,636 | C/T | — | uncertain significance |
| rs763873827 | 5:131,606,699 | C/T | — | uncertain significance |
| rs774632369 | 5:131,606,702 | C/G | — | uncertain significance |
| rs368514608 | 5:131,606,734 | G/A | — | uncertain significance |
| rs767534705 | 5:131,607,150 | G/T | — | uncertain significance |
| rs4877 | 5:131,607,588 | G/A | missense variant | — |
| rs200590141 | 5:131,607,784 | C/T | — | likely benign |
| rs1756642096 | 5:131,607,917 | G/T | — | uncertain significance |
| rs162882 | 5:131,608,291 | C/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.