PDS5B
PDS5 cohesin associated factor B
Summary
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Known Variants64 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7994229 | 13:33,160,705 | C/A | regulatory region variant | — |
| rs7321262 | 13:33,172,079 | G/T | — | — |
| rs9595893 | 13:33,175,793 | G/T | intron variant | — |
| rs9591165 | 13:33,185,153 | G/C | — | — |
| rs117964330 | 13:33,185,297 | G/A | intron variant | — |
| rs55880225 | 13:33,190,870 | T/C | intron variant | — |
| rs527749954 | 13:33,194,826 | C/T | — | — |
| rs2500557520 | 13:33,232,376 | G/T | — | uncertain significance |
| rs2500562672 | 13:33,233,343 | A/G | — | uncertain significance |
| rs185038874 | 13:33,239,130 | C/G | intron variant | — |
| rs1032700199 | 13:33,241,906 | A/C | — | uncertain significance |
| rs45580544 | 13:33,249,986 | T/C | — | benign |
| rs1230211717 | 13:33,250,081 | A/C | — | uncertain significance |
| rs201233373 | 13:33,261,295 | A/C | — | uncertain significance |
| rs1336099549 | 13:33,261,391 | C/T | — | uncertain significance |
| rs2500713062 | 13:33,261,392 | A/G | — | uncertain significance |
| rs200569285 | 13:33,262,648 | A/G | — | benign |
| rs780044352 | 13:33,262,665 | C/G | — | uncertain significance |
| rs2500750869 | 13:33,268,410 | A/G | — | uncertain significance |
| rs201690929 | 13:33,273,971 | C/G | — | uncertain significance |
| rs2500782897 | 13:33,273,992 | G/T | — | uncertain significance |
| rs1012892127 | 13:33,275,565 | G/A | — | uncertain significance |
| rs1283605513 | 13:33,281,111 | G/A | — | uncertain significance |
| rs199567336 | 13:33,284,136 | A/G | — | likely benign |
| rs2500955656 | 13:33,306,240 | C/T | — | uncertain significance |
| rs2500957786 | 13:33,306,335 | G/A | — | uncertain significance |
| rs201553782 | 13:33,309,316 | A/T | — | uncertain significance |
| rs2500997590 | 13:33,309,321 | A/T | — | uncertain significance |
| rs747614808 | 13:33,309,369 | A/G | — | uncertain significance |
| rs200545607 | 13:33,315,278 | A/G | — | uncertain significance |
| rs9591299 | 13:33,316,822 | A/G | — | uncertain significance |
| rs373562128 | 13:33,320,158 | A/G | — | uncertain significance |
| rs544071856 | 13:33,320,233 | A/G | — | uncertain significance |
| rs752499156 | 13:33,327,527 | C/T | — | uncertain significance |
| rs1163499157 | 13:33,327,620 | G/A | — | uncertain significance |
| rs1394533834 | 13:33,332,293 | A/G | — | uncertain significance |
| rs935875113 | 13:33,332,756 | G/A | — | uncertain significance |
| rs2501255899 | 13:33,332,787 | A/G | — | uncertain significance |
| rs2501279869 | 13:33,334,714 | C/T | — | uncertain significance |
| rs200178558 | 13:33,334,768 | A/G | — | uncertain significance |
| rs2501321303 | 13:33,338,711 | A/C | — | uncertain significance |
| rs2141023745 | 13:33,338,712 | G/C | — | uncertain significance |
| rs41292175 | 13:33,338,714 | C/T | — | benign |
| rs199723708 | 13:33,344,293 | C/A | — | uncertain significance |
| rs374693255 | 13:33,344,298 | G/A | — | uncertain significance |
| rs202027997 | 13:33,344,377 | G/A | — | uncertain significance |
| rs749400858 | 13:33,344,455 | T/C | — | uncertain significance |
| rs201083990 | 13:33,344,456 | A/G | — | uncertain significance |
| rs761049443 | 13:33,344,494 | A/G | — | uncertain significance |
| rs757093013 | 13:33,344,542 | A/G | — | uncertain significance |
| rs2501375009 | 13:33,344,584 | A/G | — | uncertain significance |
| rs201933867 | 13:33,344,644 | C/G | — | uncertain significance |
| rs1175667573 | 13:33,344,648 | A/C | — | uncertain significance |
| rs1160689981 | 13:33,344,663 | C/G | — | uncertain significance |
| rs747193314 | 13:33,344,833 | C/G | — | uncertain significance |
| rs761488170 | 13:33,344,877 | C/T | — | uncertain significance |
| rs561693185 | 13:33,344,898 | G/A | — | uncertain significance |
| rs773864974 | 13:33,347,328 | C/T | — | uncertain significance |
| rs367640322 | 13:33,347,337 | C/T | — | uncertain significance |
| rs776298861 | 13:33,347,350 | C/G | — | uncertain significance |
| rs2501401557 | 13:33,347,379 | G/C | — | uncertain significance |
| rs2501402822 | 13:33,347,446 | A/G | — | uncertain significance |
| rs762936755 | 13:33,347,454 | A/G | — | uncertain significance |
| rs371640955 | 13:33,347,462 | T/C | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.