PDYN

prodynorphin

Summary

The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

Known Variants173 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs886056528	20:1,959,437	G/A	—	uncertain significance
rs529380614	20:1,959,512	G/C	—	benign
rs148395893	20:1,959,526	C/T	—	benign
rs6106013	20:1,959,573	G/A	—	benign
rs112661575	20:1,959,575	G/A	—	uncertain significance
rs1402086088	20:1,959,633	C/G	—	uncertain significance
rs886056529	20:1,959,695	A/C	—	uncertain significance
rs187098720	20:1,959,731	T/A	—	likely benign
rs745852761	20:1,959,812	A/C	—	uncertain significance
rs752953257	20:1,959,898	C/T	—	conflicting classifications of pathogenicity
rs953182789	20:1,959,904	G/A	—	uncertain significance
rs2235749	20:1,959,939	G/A	3 prime UTR variant	benign
rs115095625	20:1,959,940	T/C	—	benign
rs933617446	20:1,960,097	G/T	—	uncertain significance
rs371550256	20:1,960,122	A/G	—	uncertain significance
rs80315813	20:1,960,133	G/C	—	benign
rs886056530	20:1,960,142	T/C	—	uncertain significance
rs910079	20:1,960,198	A/G	regulatory region variant	benign
rs767631485	20:1,960,209	C/G	—	conflicting classifications of pathogenicity
rs910080	20:1,960,226	A/G	regulatory region variant	benign
rs1290356604	20:1,960,298	A/G	—	uncertain significance
rs879202411	20:1,960,299	T/A	—	uncertain significance
rs10485703	20:1,960,313	A/G	—	benign
rs993395808	20:1,960,333	C/G	—	uncertain significance
rs886056531	20:1,960,408	G/A	—	uncertain significance
rs73571349	20:1,960,413	G/T	—	uncertain significance
rs886056532	20:1,960,447	G/A	—	uncertain significance
rs1987615154	20:1,960,580	T/A	—	uncertain significance
rs73894108	20:1,960,600	T/C	—	benign
rs114429882	20:1,960,613	A/G	—	benign
rs780894307	20:1,960,623	C/T	—	uncertain significance
rs1022899056	20:1,960,649	G/A	—	uncertain significance
rs886056534	20:1,960,708	G/A	—	uncertain significance
rs565210312	20:1,960,738	G/C	—	conflicting classifications of pathogenicity
rs569014510	20:1,960,744	A/G	—	benign
rs111525766	20:1,960,831	T/C	—	benign
rs555671052	20:1,960,866	G/A	—	uncertain significance
rs537887207	20:1,960,891	T/C	—	benign
rs1987645885	20:1,960,904	G/C	—	uncertain significance
rs556095353	20:1,960,936	T/G	—	likely benign
rs772841725	20:1,960,988	C/T	—	uncertain significance
rs141248791	20:1,961,002	C/T	—	benign
rs765854641	20:1,961,003	G/A	—	uncertain significance
rs754301697	20:1,961,005	A/G	—	likely benign
rs2122303556	20:1,961,007	C/T	—	uncertain significance
rs1181111571	20:1,961,010	C/T	—	uncertain significance
rs2514333411	20:1,961,011	C/G	—	uncertain significance
rs1222472109	20:1,961,016	A/T	—	uncertain significance
rs185551108	20:1,961,018	C/T	—	conflicting classifications of pathogenicity
rs112907294	20:1,961,022	T/C	—	benign
rs150953132	20:1,961,026	C/T	—	likely benign
rs774175877	20:1,961,039	C/T	—	uncertain significance
rs201204862	20:1,961,043	G/T	—	conflicting classifications of pathogenicity
rs751761506	20:1,961,060	C/T	—	uncertain significance
rs774412599	20:1,961,074	C/T	—	uncertain significance
rs754978602	20:1,961,081	A/G	—	uncertain significance
rs1214670418	20:1,961,084	T/C	—	uncertain significance
rs201655505	20:1,961,090	C/T	—	uncertain significance
rs267606939	20:1,961,091	G/A	missense variant	pathogenic
rs150455107	20:1,961,097	G/A	—	uncertain significance
rs138498390	20:1,961,099	C/T	—	conflicting classifications of pathogenicity
rs201486601	20:1,961,100	G/A	missense variant	pathogenic
rs267606940	20:1,961,102	A/G	missense variant	pathogenic
rs761983515	20:1,961,104	G/C	—	uncertain significance
rs2514334574	20:1,961,111	C/T	—	uncertain significance
rs1279805007	20:1,961,116	G/C	—	likely benign
rs575606358	20:1,961,118	G/A	—	uncertain significance
rs1185514961	20:1,961,127	G/A	—	likely benign
rs6045819	20:1,961,134	G/A	—	benign
rs949868832	20:1,961,138	C/G	—	uncertain significance
rs745446529	20:1,961,142	T/A	—	uncertain significance
rs2122307068	20:1,961,150	C/T	—	uncertain significance
rs766877230	20:1,961,151	C/T	—	uncertain significance
rs769461186	20:1,961,152	G/A	—	conflicting classifications of pathogenicity
rs45469293	20:1,961,159	T/A	—	likely benign
rs767807436	20:1,961,163	C/A	—	uncertain significance
rs2122307518	20:1,961,166	C/A	—	uncertain significance
rs773424079	20:1,961,168	A/C	—	uncertain significance
rs2514335331	20:1,961,169	C/T	—	uncertain significance
rs1600504981	20:1,961,173	T/G	—	likely benign
rs1987686544	20:1,961,187	G/T	—	uncertain significance
rs377075531	20:1,961,195	C/T	—	uncertain significance
rs370283678	20:1,961,196	G/A	—	uncertain significance
rs781094877	20:1,961,204	C/T	—	uncertain significance
rs2514335634	20:1,961,206	C/T	—	likely benign
rs1472967766	20:1,961,207	C/T	—	uncertain significance
rs567558964	20:1,961,214	G/A	—	conflicting classifications of pathogenicity
rs2514335903	20:1,961,225	T/A	—	uncertain significance
rs1242938963	20:1,961,231	G/T	—	uncertain significance
rs886056535	20:1,961,233	G/A	—	uncertain significance
rs376124198	20:1,961,244	C/T	—	conflicting classifications of pathogenicity
rs774940143	20:1,961,245	G/A	—	likely benign
rs773513924	20:1,961,251	G/C	—	likely benign
rs144748816	20:1,961,258	C/T	—	conflicting classifications of pathogenicity
rs1255371062	20:1,961,275	A/G	—	likely benign
rs1171241754	20:1,961,277	C/T	—	conflicting classifications of pathogenicity
rs148113209	20:1,961,278	G/A	—	likely benign
rs1166439244	20:1,961,290	A/G	—	likely benign
rs751547542	20:1,961,297	A/T	—	uncertain significance
rs77155664	20:1,961,298	T/G	—	likely benign

Showing 100 of 173 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.