PHACTR3
phosphatase and actin regulator 3
Summary
This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Known Variants44 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs865912633 | 20:58,152,579 | G/T | — | uncertain significance |
| rs961562111 | 20:58,152,582 | G/T | — | uncertain significance |
| rs529364540 | 20:58,152,634 | C/T | — | uncertain significance |
| rs73138896 | 20:58,161,562 | T/A | intron variant | — |
| rs1014490316 | 20:58,167,065 | A/G | — | — |
| rs6026990 | 20:58,177,615 | T/A | upstream gene variant | — |
| rs979998508 | 20:58,180,080 | C/G | — | uncertain significance |
| rs2515997142 | 20:58,180,151 | T/G | — | uncertain significance |
| rs117431198 | 20:58,219,763 | C/T | intron variant | — |
| rs6123924 | 20:58,219,764 | A/C | — | — |
| rs779516285 | 20:58,322,833 | G/A | — | uncertain significance |
| rs2039428587 | 20:58,322,846 | G/A | — | uncertain significance |
| rs368361108 | 20:58,330,293 | C/T | — | uncertain significance |
| rs371300986 | 20:58,330,353 | G/C | — | uncertain significance |
| rs769085947 | 20:58,342,249 | C/A | — | uncertain significance |
| rs762117641 | 20:58,342,265 | G/A | — | uncertain significance |
| rs756121564 | 20:58,342,304 | A/G | — | uncertain significance |
| rs2516668692 | 20:58,342,345 | A/G | — | uncertain significance |
| rs201118563 | 20:58,342,389 | C/A | — | uncertain significance |
| rs139799389 | 20:58,342,409 | C/T | — | uncertain significance |
| rs934646941 | 20:58,348,348 | T/C | — | uncertain significance |
| rs766146546 | 20:58,348,354 | G/A | — | uncertain significance |
| rs747154584 | 20:58,348,391 | G/A | — | uncertain significance |
| rs199947940 | 20:58,348,403 | C/T | — | uncertain significance |
| rs1039165961 | 20:58,348,418 | C/T | — | uncertain significance |
| rs1374194548 | 20:58,348,439 | G/A | — | uncertain significance |
| rs373371486 | 20:58,348,447 | C/G | — | uncertain significance |
| rs770872817 | 20:58,348,456 | C/A | — | uncertain significance |
| rs2516706443 | 20:58,349,332 | A/C | — | uncertain significance |
| rs201357222 | 20:58,349,354 | C/T | — | uncertain significance |
| rs148881167 | 20:58,349,368 | G/A | — | likely benign |
| rs189794958 | 20:58,349,500 | C/A | — | uncertain significance |
| rs145724526 | 20:58,349,530 | G/A | — | uncertain significance |
| rs1170169909 | 20:58,349,536 | A/G | — | uncertain significance |
| rs1182512 | 20:58,363,678 | T/G | — | — |
| rs375163958 | 20:58,381,176 | C/T | — | uncertain significance |
| rs2041562184 | 20:58,381,202 | T/G | — | uncertain significance |
| rs1182531 | 20:58,393,002 | G/T | intron variant | — |
| rs1182532 | 20:58,393,545 | C/A | intron variant | — |
| rs138964292 | 20:58,411,562 | G/A | — | uncertain significance |
| rs374188338 | 20:58,415,439 | C/T | — | uncertain significance |
| rs2059036832 | 20:58,415,442 | A/G | — | uncertain significance |
| rs1396709249 | 20:58,415,454 | G/A | — | uncertain significance |
| rs1367179711 | 20:58,416,502 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.