PHLDB2

pleckstrin homology like domain family B member 2

Summary

Enables cadherin binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; regulation of cytoskeleton organization; and regulation of embryonic development. Located in several cellular components, including basal cortex; cytoskeleton; and focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]

Known Variants84 total

rsidPosition (GRCh37)AllelesClassClinVar
rs286750793:111,500,002G/Aintron variant
rs98432883:111,504,556T/Aintron variant
rs98804953:111,525,552T/C
rs98299683:111,535,358T/Aintron variant
rs3777389103:111,564,743G/Auncertain significance
rs12829803:111,572,321T/Cintron variant
rs732285433:111,592,838G/Aregulatory region variant
rs5659873913:111,602,979G/Cuncertain significance
rs10369761253:111,603,034G/Auncertain significance
rs3733639613:111,603,036C/Guncertain significance
rs5388141613:111,603,055C/Tuncertain significance
rs342514363:111,603,061G/Tbenign
rs3700802163:111,603,217G/Auncertain significance
rs2017264253:111,603,252C/Tuncertain significance
rs20660755303:111,603,300G/Auncertain significance
rs7580626453:111,603,318A/Guncertain significance
rs7468157403:111,603,325G/Auncertain significance
rs7571908703:111,603,330A/Guncertain significance
rs1432202653:111,603,355A/Tuncertain significance
rs7646720703:111,603,398T/Auncertain significance
rs9744592063:111,603,459A/Guncertain significance
rs753572073:111,603,496C/Tbenign
rs24726392593:111,603,540A/Cuncertain significance
rs3757156303:111,603,557G/Auncertain significance
rs7537628853:111,603,576G/Tuncertain significance
rs5531690563:111,603,577C/Tuncertain significance
rs2009417113:111,603,598G/Cuncertain significance
rs11998842543:111,603,607A/Guncertain significance
rs2011714213:111,603,790A/Guncertain significance
rs7774636293:111,603,823A/Guncertain significance
rs20660902693:111,603,927C/Tuncertain significance
rs15769937453:111,603,960A/Guncertain significance
rs11719287213:111,603,963T/Auncertain significance
rs3722102883:111,604,045A/Guncertain significance
rs2021302943:111,604,057C/Tuncertain significance
rs2017260323:111,604,158C/Guncertain significance
rs7792124423:111,604,212C/Tuncertain significance
rs7723796283:111,604,215C/Tuncertain significance
rs16320323:111,613,902G/A
rs7497579913:111,632,175C/Tuncertain significance
rs7766952613:111,632,227G/Auncertain significance
rs14496842193:111,632,269A/Guncertain significance
rs2004601223:111,632,422G/Auncertain significance
rs12875089533:111,632,481C/Tuncertain significance
rs7569532723:111,632,485C/Tuncertain significance
rs357752353:111,632,498C/Tbenign
rs24728115363:111,632,512C/Tuncertain significance
rs5463273973:111,632,524C/Guncertain significance
rs2001590783:111,637,946A/Guncertain significance
rs1488986423:111,637,980G/Tuncertain significance
rs9516603:111,638,132A/T
rs5307007763:111,639,166A/Tuncertain significance
rs1488099653:111,639,187T/Cuncertain significance
rs3737859183:111,639,219C/Tuncertain significance
rs12346300103:111,658,397C/Guncertain significance
rs3717949733:111,658,436C/Tuncertain significance
rs2001799343:111,664,140A/Guncertain significance
rs355062323:111,664,191A/Gbenign
rs2012493743:111,667,840C/Guncertain significance
rs1415048363:111,667,867C/Guncertain significance
rs1489117853:111,667,900C/Tlikely benign
rs345422093:111,667,901G/Abenign
rs24730561223:111,671,480C/Tuncertain significance
rs24730651543:111,672,807T/Cuncertain significance
rs799942653:111,672,822C/Tbenign
rs5301265333:111,672,823C/Tuncertain significance
rs14362807413:111,672,837G/Tuncertain significance
rs340818873:111,672,861C/Tbenign
rs98500113:111,672,880C/Tbenign
rs3740546883:111,680,961A/Guncertain significance
rs24731454153:111,685,464A/Guncertain significance
rs1448527553:111,685,533C/Tuncertain significance
rs1485747923:111,685,534G/Auncertain significance
rs10151414733:111,685,536C/Auncertain significance
rs3707954503:111,685,542G/Auncertain significance
rs7802508953:111,686,528C/Tuncertain significance
rs1465451013:111,688,552C/Tuncertain significance
rs5613106613:111,688,553G/Auncertain significance
rs7609558643:111,688,556A/Cuncertain significance
rs1413173213:111,688,567C/Tuncertain significance
rs7697508483:111,688,625C/Tuncertain significance
rs1380930203:111,692,636A/Guncertain significance
rs9637320963:111,693,393A/Cuncertain significance
rs7571403493:111,693,394C/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.