rs73228543

This is a regulatory region variant variant in the PHLDB2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atrial fibrillation

Roselli C et al. “Multi-ethnic genome-wide association study for atrial fibrillation.” Nature Genetics 50(9):1225-1233 (2018)

Allele G

OR 1.07

p 3.0e-11

N 588,190

Large GWAS

multi-ancestry

About PHLDB2

Enables cadherin binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; regulation of cytoskeleton organization; and regulation of embryonic development. Located in several cellular components, including basal cortex; cytoskeleton; and focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]

View all PHLDB2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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