PHLPP2

PH domain and leucine rich repeat protein phosphatase 2

Summary

Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cilium; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2025]

Known Variants90 total

rsidPosition (GRCh37)AllelesClassClinVar
rs20114145316:71,682,803G/Auncertain significance
rs74749242316:71,682,896T/Auncertain significance
rs14970557616:71,682,911T/Clikely benign
rs204467390916:71,682,912G/Tuncertain significance
rs78084246716:71,682,917A/Guncertain significance
rs92984751916:71,683,218G/Auncertain significance
rs250776934916:71,683,244C/Auncertain significance
rs14049580016:71,683,293C/Tuncertain significance
rs77630402316:71,683,317C/Guncertain significance
rs55119390316:71,683,329C/Tuncertain significance
rs57733764116:71,683,339C/Auncertain significance
rs19981151016:71,683,349G/Clikely benign
rs129851244816:71,683,391G/Tuncertain significance
rs36846995916:71,683,398T/Guncertain significance
rs14914192116:71,683,418C/Tuncertain significance
rs78081957216:71,683,430G/Auncertain significance
rs75778394516:71,683,500C/Auncertain significance
rs204468097116:71,683,547C/Tuncertain significance
rs142392184816:71,683,593T/Cuncertain significance
rs76534619516:71,683,605C/Tuncertain significance
rs76890155716:71,683,706T/Cuncertain significance
rs14228706316:71,683,759G/Abenign
rs36827419816:71,683,830A/Tuncertain significance
rs75798777916:71,683,850G/Auncertain significance
rs14247270216:71,686,790C/Tuncertain significance
rs6173312816:71,686,811G/Auncertain significance
rs76529435416:71,686,856G/Tuncertain significance
rs56970313816:71,686,866G/Cuncertain significance
rs13908791216:71,686,904T/Cuncertain significance
rs75891621116:71,689,147G/Cuncertain significance
rs75975630716:71,689,227G/Auncertain significance
rs75307908916:71,689,242C/Tuncertain significance
rs75205413216:71,689,260C/Tuncertain significance
rs250778468016:71,689,269T/Auncertain significance
rs120046137216:71,689,304A/Cuncertain significance
rs78012242016:71,690,543G/Cuncertain significance
rs1205144316:71,691,329G/Aintron variant
rs53632420216:71,692,667C/Auncertain significance
rs14481854616:71,693,773C/Gintron variant
rs14472565516:71,697,889G/Auncertain significance
rs75106179916:71,697,953C/Tuncertain significance
rs75016665116:71,697,961A/Guncertain significance
rs14041092016:71,697,964G/Auncertain significance
rs74589802316:71,701,117G/Auncertain significance
rs126241914316:71,703,251C/Tuncertain significance
rs11306173416:71,703,264T/Clikely benign
rs1292463116:71,705,774G/Aintron variant
rs77848143416:71,706,174T/Cuncertain significance
rs133098841916:71,706,180A/Glikely benign
rs96834919016:71,710,373C/Tuncertain significance
rs37771219216:71,710,374G/Auncertain significance
rs14858409116:71,710,408C/Glikely benign
rs55083788816:71,710,463T/Cuncertain significance
rs204497067816:71,712,715T/Cuncertain significance
rs101848416016:71,712,779T/Cuncertain significance
rs74963079716:71,712,815A/Guncertain significance
rs133355787516:71,712,827G/Cuncertain significance
rs125101908816:71,712,863T/Cuncertain significance
rs75519217716:71,713,323C/Guncertain significance
rs37114754516:71,713,346T/Cuncertain significance
rs14521654216:71,713,348G/Alikely benign
rs14890187816:71,713,383T/Clikely benign
rs148504433416:71,713,407G/Auncertain significance
rs77440648216:71,715,717T/Cuncertain significance
rs77867401216:71,715,764G/Cuncertain significance
rs11316627116:71,715,768T/Cuncertain significance
rs247934061216:71,715,771C/Auncertain significance
rs18994656216:71,718,392C/Tuncertain significance
rs99669224016:71,718,447C/Guncertain significance
rs75014298416:71,718,464C/Guncertain significance
rs14464143416:71,718,504T/Clikely benign
rs7806460716:71,723,181C/Tintron variant
rs76417820316:71,724,438G/Auncertain significance
rs36915631416:71,724,485G/Cuncertain significance
rs254345024016:71,736,524C/Guncertain significance
rs37422995416:71,736,558G/Auncertain significance
rs7678873516:71,743,169T/Cregulatory region variant
rs720321616:71,745,518C/G
rs76234038716:71,748,434G/Cuncertain significance
rs55823957816:71,748,481G/Auncertain significance
rs57630993716:71,748,482C/Auncertain significance
rs76221768316:71,748,510A/Tuncertain significance
rs126294897416:71,748,515A/Tuncertain significance
rs76593264416:71,748,520G/Auncertain significance
rs254346540216:71,748,529G/Auncertain significance
rs13791037316:71,748,544G/Cuncertain significance
rs254346545116:71,748,547G/Auncertain significance
rs77339647516:71,748,592T/Cuncertain significance
rs19248087616:71,748,677T/Guncertain significance
rs74631325416:71,748,692G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.