PRUNE1

prune exopolyphosphatase 1

Summary

This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Known Variants113 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1232331611	1:150,981,111	G/A	—	likely pathogenic
rs112740880	1:150,981,138	T/C	—	likely benign
rs2528289273	1:150,981,142	C/T	—	likely benign
rs1475063855	1:150,981,144	G/A	—	likely benign
rs756542737	1:150,981,148	G/T	—	likely pathogenic
rs1384222371	1:150,981,160	T/G	—	likely benign
rs186222624	1:150,985,323	C/T	upstream gene variant	—
rs1393865647	1:150,990,274	T/A	—	likely benign
rs149560167	1:150,990,292	C/T	—	benign
rs764540867	1:150,990,295	G/A	—	uncertain significance
rs138499343	1:150,990,304	A/G	—	uncertain significance
rs765922154	1:150,990,319	A/G	—	uncertain significance
rs1057521927	1:150,990,336	G/A	missense variant	pathogenic
rs756008936	1:150,990,363	G/C	—	uncertain significance
rs1674200670	1:150,990,382	T/C	—	pathogenic
rs771243723	1:150,990,387	A/G	—	uncertain significance
rs376514773	1:150,990,395	G/A	—	likely benign
rs1674202187	1:150,990,398	G/T	—	likely benign
rs771794927	1:150,990,923	C/T	—	likely benign
rs2528343844	1:150,990,930	C/T	—	likely benign
rs1360812866	1:150,990,951	G/A	—	likely benign
rs1085308033	1:150,990,970	C/A	missense variant	pathogenic
rs2528344083	1:150,990,980	A/G	—	uncertain significance
rs2528344099	1:150,990,982	A/G	—	uncertain significance
rs752265682	1:150,990,988	C/T	—	uncertain significance
rs751943099	1:150,990,989	G/A	—	uncertain significance
rs137929776	1:150,991,006	C/T	stop gained	pathogenic
rs373101423	1:150,991,007	G/A	—	uncertain significance
rs201533073	1:150,991,069	G/A	—	uncertain significance
rs866471269	1:150,991,074	G/C	—	uncertain significance
rs757889333	1:150,991,083	C/G	—	likely benign
rs1674240509	1:150,991,095	C/G	—	pathogenic
rs2528344754	1:150,991,100	C/G	—	uncertain significance
rs1558077514	1:150,991,104	C/A	—	likely benign
rs773618224	1:150,991,126	G/A	missense variant	pathogenic
rs147167297	1:150,991,132	C/T	—	uncertain significance
rs1674244938	1:150,991,151	C/T	—	uncertain significance
rs367588402	1:150,991,152	A/G	—	likely benign
rs191559740	1:150,994,828	C/A	downstream gene variant	—
rs762922023	1:150,997,120	G/C	—	uncertain significance
rs988161586	1:150,997,124	C/T	—	likely benign
rs373829588	1:150,997,129	C/T	—	likely benign
rs1245016196	1:150,997,131	A/G	—	likely pathogenic
rs587684563	1:150,997,133	C/T	—	likely pathogenic
rs767769359	1:150,997,134	G/A	missense variant	pathogenic
rs112180991	1:150,997,141	C/T	—	likely benign
rs186350294	1:150,997,142	G/C	—	uncertain significance
rs1040739380	1:150,997,145	C/T	—	uncertain significance
rs56805474	1:150,997,155	G/A	—	benign
rs1035705156	1:150,997,158	C/G	—	uncertain significance
rs587670646	1:150,997,186	G/A	—	likely benign
rs1674713735	1:150,997,187	G/T	—	uncertain significance
rs139698394	1:150,997,210	C/T	—	likely benign
rs140659891	1:150,997,211	G/A	—	benign
rs2528381637	1:150,997,254	C/T	—	uncertain significance
rs769528628	1:150,997,257	C/T	—	uncertain significance
rs2528381693	1:150,997,266	T/C	—	pathogenic
rs200618384	1:150,997,271	G/T	stop gained	pathogenic
rs886039608	1:150,997,989	A/G	—	pathogenic
rs2528385919	1:150,998,008	T/C	—	uncertain significance
rs1456845940	1:150,998,010	T/A	—	pathogenic
rs1426975986	1:150,998,039	C/T	—	uncertain significance
rs776842998	1:150,998,049	G/A	—	likely benign
rs777317009	1:150,998,061	T/C	—	likely benign
rs1674782840	1:150,998,101	A/T	—	uncertain significance
rs753571671	1:150,998,107	G/A	—	uncertain significance
rs150450383	1:150,998,110	A/G	—	conflicting classifications of pathogenicity
rs2528387097	1:150,998,140	G/A	—	uncertain significance
rs368861169	1:150,999,699	T/A	—	uncertain significance
rs11204762	1:150,999,737	G/A	—	benign
rs374433339	1:150,999,764	C/T	—	likely benign
rs139834881	1:150,999,765	G/A	—	benign
rs868351547	1:150,999,776	C/T	—	likely benign
rs587757975	1:150,999,792	A/G	—	likely benign
rs369633480	1:150,999,814	G/A	—	likely benign
rs375075519	1:151,001,245	C/T	—	likely benign
rs113421727	1:151,001,246	G/A	—	benign
rs755878294	1:151,001,252	T/G	—	likely benign
rs934070768	1:151,001,270	G/C	—	likely benign
rs775863253	1:151,001,285	C/T	—	likely benign
rs1553254265	1:151,001,296	T/C	—	likely pathogenic
rs2528409483	1:151,001,309	C/T	—	likely benign
rs752599948	1:151,001,376	C/T	missense variant	pathogenic
rs1558088029	1:151,001,388	A/G	—	uncertain significance
rs139153854	1:151,001,419	C/T	—	uncertain significance
rs747498357	1:151,001,420	G/A	—	uncertain significance
rs11204763	1:151,003,669	G/T	—	—
rs1199288067	1:151,006,263	G/A	—	likely benign
rs201713554	1:151,006,266	A/T	—	benign
rs748585612	1:151,006,267	T/C	—	likely benign
rs144150015	1:151,006,310	C/T	—	uncertain significance
rs2528438785	1:151,006,353	C/A	—	uncertain significance
rs369087771	1:151,006,364	A/G	—	conflicting classifications of pathogenicity
rs72706548	1:151,006,406	C/G	—	likely benign
rs2528439435	1:151,006,439	A/T	—	uncertain significance
rs2528439516	1:151,006,448	A/C	—	uncertain significance
rs752752251	1:151,006,457	C/G	—	uncertain significance
rs780894585	1:151,006,518	A/G	—	likely benign
rs202072956	1:151,006,520	G/A	—	uncertain significance
rs3738477	1:151,006,537	G/A	—	benign

Showing 100 of 113 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.