PTGR1
prostaglandin reductase 1
Summary
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Known Variants35 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7852169 | 9:114,318,394 | C/T | — | — |
| rs10980942 | 9:114,318,773 | G/T | — | — |
| rs201774010 | 9:114,325,474 | A/T | — | uncertain significance |
| rs1231701720 | 9:114,325,490 | A/G | — | likely benign |
| rs111703901 | 9:114,325,819 | T/C | intron variant | — |
| rs112140014 | 9:114,325,849 | G/C | intron variant | — |
| rs146469061 | 9:114,332,369 | A/G | splice region variant | — |
| rs140536268 | 9:114,332,397 | T/C | — | uncertain significance |
| rs2538531533 | 9:114,332,399 | A/G | — | uncertain significance |
| rs115758301 | 9:114,332,412 | G/A | — | likely benign |
| rs752265017 | 9:114,332,430 | G/A | — | uncertain significance |
| rs777882674 | 9:114,332,436 | C/T | — | uncertain significance |
| rs149211975 | 9:114,332,453 | C/T | — | likely benign |
| rs74308680 | 9:114,333,128 | A/G | upstream gene variant | — |
| rs77928057 | 9:114,335,345 | G/T | — | — |
| rs776282913 | 9:114,337,020 | G/T | — | uncertain significance |
| rs765255308 | 9:114,337,023 | G/A | — | uncertain significance |
| rs1326521149 | 9:114,337,035 | T/C | — | uncertain significance |
| rs141651182 | 9:114,337,062 | T/C | — | uncertain significance |
| rs146199919 | 9:114,337,092 | C/T | — | likely benign |
| rs185996312 | 9:114,337,956 | G/A | downstream gene variant | — |
| rs775148986 | 9:114,341,092 | T/C | — | uncertain significance |
| rs750630020 | 9:114,341,110 | G/A | — | uncertain significance |
| rs141717707 | 9:114,341,147 | T/C | — | uncertain significance |
| rs201572502 | 9:114,341,159 | C/T | — | uncertain significance |
| rs150558372 | 9:114,341,162 | C/T | — | uncertain significance |
| rs79129665 | 9:114,341,221 | A/G | — | uncertain significance |
| rs74633160 | 9:114,341,240 | A/G | — | benign |
| rs764897605 | 9:114,345,767 | C/A | — | uncertain significance |
| rs375025856 | 9:114,348,308 | G/C | — | uncertain significance |
| rs2538587222 | 9:114,348,368 | A/G | — | uncertain significance |
| rs140662657 | 9:114,348,373 | G/C | — | uncertain significance |
| rs763179462 | 9:114,348,375 | G/A | — | uncertain significance |
| rs2273788 | 9:114,348,617 | C/T | intron variant | — |
| rs199615972 | 9:114,356,542 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.