rs7852169

This variant is located in the PTGR1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

age at menarche

Sarnowski C et al. “Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche.” Human Reproduction (oxford, England) 36(7):1999-2010 (2021)

Allele C

OR 0.09

p 1.0e-8

N 38,546

Meta-analysisLarge GWAS

multi-ancestry

puberty onset measurement

Hollis B et al. “Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan.” Nature Communications 11(1):1536 (2020)

Allele G

OR 0.01

p 2.0e-8

N 187,241

Large GWAS

European

About PTGR1

This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

View all PTGR1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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