PTGS2
prostaglandin-endoperoxide synthase 2
Summary
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
Known Variants46 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4648310 | 1:186,640,525 | T/G | — | — |
| rs4648308 | 1:186,640,617 | C/T | downstream gene variant | — |
| rs689470 | 1:186,641,058 | G/C | — | — |
| rs689469 | 1:186,641,197 | C/T | 3 prime UTR variant | — |
| rs4648298 | 1:186,641,682 | T/C | 3 prime UTR variant | — |
| rs13306035 | 1:186,641,847 | A/G | — | — |
| rs2206593 | 1:186,642,429 | A/G | 3 prime UTR variant | — |
| rs5276 | 1:186,642,987 | C/T | 3 prime UTR variant | — |
| rs5275 | 1:186,643,058 | A/G | 3 prime UTR variant | other |
| rs1665742526 | 1:186,643,516 | A/G | — | uncertain significance |
| rs148865858 | 1:186,643,533 | A/G | — | likely benign |
| rs3218625 | 1:186,643,541 | C/T | missense variant | — |
| rs5274 | 1:186,643,545 | G/T | — | benign |
| rs2526384097 | 1:186,643,558 | G/C | — | uncertain significance |
| rs774122358 | 1:186,643,567 | G/C | — | uncertain significance |
| rs201922079 | 1:186,643,714 | G/A | — | uncertain significance |
| rs4648288 | 1:186,643,803 | C/T | — | likely benign |
| rs752484376 | 1:186,643,877 | C/T | — | uncertain significance |
| rs777664238 | 1:186,643,887 | C/G | — | uncertain significance |
| rs139215497 | 1:186,644,480 | C/A | — | uncertain significance |
| rs1179716081 | 1:186,645,022 | A/G | — | likely benign |
| rs5279 | 1:186,645,078 | A/G | — | benign |
| rs147906320 | 1:186,645,189 | T/C | — | likely benign |
| rs4648276 | 1:186,645,488 | A/G | upstream gene variant | — |
| rs5278 | 1:186,645,669 | A/G | — | benign |
| rs2066826 | 1:186,645,927 | C/T | upstream gene variant | — |
| rs1181816669 | 1:186,645,968 | A/G | — | likely benign |
| rs764444040 | 1:186,646,057 | T/G | — | likely benign |
| rs535541309 | 1:186,646,887 | T/C | — | uncertain significance |
| rs4648266 | 1:186,647,384 | C/T | — | benign |
| rs20429 | 1:186,647,460 | G/A | — | likely benign |
| rs965556832 | 1:186,647,470 | G/C | — | uncertain significance |
| rs5277 | 1:186,648,197 | C/T | synonymous variant | — |
| rs1378833561 | 1:186,648,204 | C/T | — | uncertain significance |
| rs773231889 | 1:186,648,245 | G/A | — | likely benign |
| rs764773998 | 1:186,648,286 | T/C | — | uncertain significance |
| rs4648262 | 1:186,648,749 | C/A | upstream gene variant | — |
| rs4648261 | 1:186,649,004 | C/T | regulatory region variant | — |
| rs2745557 | 1:186,649,221 | A/T | — | — |
| rs20426 | 1:186,649,420 | C/T | missense variant | — |
| rs5270 | 1:186,649,719 | G/C | regulatory region variant | — |
| rs20417 | 1:186,650,321 | C/G | coding sequence variant | other |
| rs20415 | 1:186,650,688 | C/T | regulatory region variant | — |
| rs689466 | 1:186,650,751 | T/C | upstream gene variant | — |
| rs689465 | 1:186,650,846 | T/C | regulatory region variant | — |
| rs689462 | 1:186,651,083 | T/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.