rs689469
This is a 3 prime utr variant variant in the PTGS2 gene.
▶Research that mentions this SNP (1)
▶Cyclooxygenase‐2 polymorphisms in Parkinson's diseaseAssociationN=591Anna Håkansson et al.(2007)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A case-control study in Brazilian women investigating the association between PTGS2 (COX-2) gene polymorphisms and breast cancer risk. The study identified nine SNPs in the promoter and 3'-UTR regions, with four frequent SNPs (rs689465, rs689466, rs20417, rs5275) selected for analysis. While rs5275 TC heterozygotes showed increased frequency in cases (OR=1.44, P=0.043), the authors concluded there was no strong association between the most frequent PTGS2 SNPs and breast cancer risk.
About PTGS2
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
View all PTGS2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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