QARS1
glutaminyl-tRNA synthetase 1
Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Known Variants776 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1343527647 | 3:49,133,465 | C/T | — | likely benign |
| rs373300144 | 3:49,133,470 | T/C | — | uncertain significance |
| rs762570876 | 3:49,133,473 | C/T | — | uncertain significance |
| rs376870623 | 3:49,133,477 | G/A | — | likely benign |
| rs1388810452 | 3:49,133,478 | T/G | — | uncertain significance |
| rs754648501 | 3:49,133,479 | C/T | — | uncertain significance |
| rs767099836 | 3:49,133,486 | C/T | — | likely benign |
| rs1291965738 | 3:49,133,499 | C/T | — | uncertain significance |
| rs746327492 | 3:49,133,500 | G/A | — | uncertain significance |
| rs534624263 | 3:49,133,516 | G/A | — | likely benign |
| rs776993371 | 3:49,133,525 | G/C | — | likely benign |
| rs143986230 | 3:49,133,552 | C/T | — | likely benign |
| rs1215632056 | 3:49,135,407 | G/T | — | likely benign |
| rs752322988 | 3:49,135,416 | G/A | — | likely benign |
| rs2042412962 | 3:49,135,422 | C/T | — | uncertain significance |
| rs1193194264 | 3:49,135,424 | C/G | — | uncertain significance |
| rs1324687960 | 3:49,135,425 | C/A | — | uncertain significance |
| rs1426097729 | 3:49,135,432 | T/C | — | uncertain significance |
| rs2042413109 | 3:49,135,437 | G/C | — | uncertain significance |
| rs142480574 | 3:49,135,441 | T/C | — | uncertain significance |
| rs751751662 | 3:49,135,449 | C/A | — | likely benign |
| rs781617872 | 3:49,135,451 | C/T | — | uncertain significance |
| rs748351582 | 3:49,135,452 | G/T | — | likely benign |
| rs1293778465 | 3:49,135,453 | G/A | — | uncertain significance |
| rs140358033 | 3:49,135,464 | A/C | — | likely benign |
| rs770019480 | 3:49,135,468 | C/T | — | uncertain significance |
| rs1234673016 | 3:49,135,469 | G/A | — | uncertain significance |
| rs370685207 | 3:49,135,476 | C/A | — | uncertain significance |
| rs1282040984 | 3:49,135,479 | G/C | — | uncertain significance |
| rs777452461 | 3:49,135,482 | C/G | — | uncertain significance |
| rs925254000 | 3:49,135,484 | T/G | — | uncertain significance |
| rs749055007 | 3:49,135,487 | C/A | — | uncertain significance |
| rs772699618 | 3:49,135,492 | G/A | — | uncertain significance |
| rs527864842 | 3:49,135,493 | G/T | — | uncertain significance |
| rs763741745 | 3:49,135,507 | A/G | — | uncertain significance |
| rs1449000257 | 3:49,135,509 | A/T | — | uncertain significance |
| rs1377061002 | 3:49,135,518 | C/G | — | likely benign |
| rs913919560 | 3:49,135,528 | G/A | — | uncertain significance |
| rs2042414825 | 3:49,135,529 | C/G | — | uncertain significance |
| rs200663794 | 3:49,135,530 | A/G | — | likely benign |
| rs2042414914 | 3:49,135,532 | C/G | — | uncertain significance |
| rs2471842700 | 3:49,135,535 | C/G | — | uncertain significance |
| rs752094317 | 3:49,135,536 | C/A | — | likely benign |
| rs781454677 | 3:49,135,538 | C/T | — | uncertain significance |
| rs752777280 | 3:49,135,539 | G/A | — | likely benign |
| rs756304792 | 3:49,135,548 | T/C | — | likely benign |
| rs1332410993 | 3:49,135,549 | G/A | — | uncertain significance |
| rs2042415174 | 3:49,135,550 | C/G | — | uncertain significance |
| rs1293403830 | 3:49,135,557 | G/A | — | likely benign |
| rs1057524221 | 3:49,135,559 | A/G | — | likely benign |
| rs749104266 | 3:49,135,560 | G/A | — | likely benign |
| rs373696203 | 3:49,135,561 | G/C | — | likely benign |
| rs2107095116 | 3:49,135,562 | G/C | — | likely benign |
| rs2107095137 | 3:49,135,570 | G/T | — | likely benign |
| rs1465310490 | 3:49,135,612 | C/G | — | likely benign |
| rs367692530 | 3:49,135,613 | T/C | — | likely benign |
| rs774818694 | 3:49,135,614 | C/A | — | likely benign |
| rs2471843024 | 3:49,135,617 | G/A | — | likely benign |
| rs760143907 | 3:49,135,627 | G/C | — | uncertain significance |
| rs2471843045 | 3:49,135,633 | G/A | — | likely benign |
| rs752830145 | 3:49,135,634 | G/T | — | uncertain significance |
| rs376686675 | 3:49,135,640 | T/C | — | likely benign |
| rs1379211376 | 3:49,135,646 | T/G | — | likely benign |
| rs142327602 | 3:49,135,653 | G/A | — | conflicting classifications of pathogenicity |
| rs778699748 | 3:49,135,654 | G/C | — | uncertain significance |
| rs2471843153 | 3:49,135,660 | C/T | — | uncertain significance |
| rs2471843158 | 3:49,135,662 | G/T | — | uncertain significance |
| rs527504481 | 3:49,135,666 | G/C | — | uncertain significance |
| rs2107095526 | 3:49,135,672 | C/T | — | uncertain significance |
| rs1312228877 | 3:49,135,673 | A/G | — | likely benign |
| rs2471843215 | 3:49,135,676 | G/A | — | likely benign |
| rs2107095560 | 3:49,135,679 | C/T | — | likely benign |
| rs2042417727 | 3:49,135,683 | T/G | — | uncertain significance |
| rs369669069 | 3:49,135,684 | G/A | — | uncertain significance |
| rs1227040183 | 3:49,135,685 | C/T | — | likely benign |
| rs2042417825 | 3:49,135,689 | A/C | — | uncertain significance |
| rs2042417862 | 3:49,135,693 | T/C | — | likely pathogenic |
| rs1024765171 | 3:49,135,694 | G/T | — | likely pathogenic |
| rs1352118586 | 3:49,135,695 | C/T | — | likely benign |
| rs2471843308 | 3:49,135,697 | G/A | — | likely benign |
| rs549153964 | 3:49,135,703 | G/C | — | uncertain significance |
| rs887349442 | 3:49,135,704 | T/A | — | likely benign |
| rs1280267884 | 3:49,135,705 | G/C | — | likely benign |
| rs2471843344 | 3:49,135,708 | G/A | — | likely benign |
| rs1005774254 | 3:49,135,709 | G/A | — | likely benign |
| rs114149286 | 3:49,135,764 | C/A | — | likely benign |
| rs2471843589 | 3:49,135,767 | C/T | — | uncertain significance |
| rs1269031366 | 3:49,135,772 | C/T | — | likely benign |
| rs1451748786 | 3:49,135,774 | C/T | — | likely benign |
| rs79363335 | 3:49,135,785 | C/A | — | likely pathogenic |
| rs376482152 | 3:49,135,787 | G/C | — | uncertain significance |
| rs772994973 | 3:49,135,789 | C/T | — | uncertain significance |
| rs746293241 | 3:49,135,790 | G/A | — | pathogenic |
| rs557972227 | 3:49,135,795 | T/C | — | uncertain significance |
| rs138588649 | 3:49,135,797 | G/A | — | likely benign |
| rs778797651 | 3:49,135,799 | G/C | — | uncertain significance |
| rs201781920 | 3:49,135,801 | C/T | — | uncertain significance |
| rs370934093 | 3:49,135,802 | G/A | missense variant | uncertain significance |
| rs144316335 | 3:49,135,806 | C/T | — | likely benign |
| rs761792999 | 3:49,135,809 | A/G | — | likely benign |
Showing 100 of 776 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.