RAD51D

RAD51 paralog D

Summary

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]

Known Variants1,086 total

rsidPosition (GRCh37)AllelesClassClinVar
rs2836329217:33,427,842T/G—benign
rs209152638117:33,427,923G/T—likely benign
rs37493964217:33,427,956C/A—uncertain significance
rs209152678417:33,427,961A/G—uncertain significance
rs75950212217:33,427,962A/T—likely benign
rs37098567517:33,427,965G/A—conflicting classifications of pathogenicity
rs87665902617:33,427,968C/T—conflicting classifications of pathogenicity
rs209152690717:33,427,972T/C—uncertain significance
rs159785529317:33,427,973C/A—uncertain significance
rs137690023917:33,427,974A/G—uncertain significance
rs159785529717:33,427,975T/C—likely benign
rs13896959517:33,427,976G/A—likely benign
rs209152710417:33,427,977T/A—conflicting classifications of pathogenicity
rs214240860017:33,427,978C/T—likely benign
rs209152714817:33,427,979T/A—uncertain significance
rs78620397417:33,427,980G/A—uncertain significance
rs155556693517:33,427,982T/G—uncertain significance
rs214240866017:33,427,985C/T—uncertain significance
rs58778010617:33,427,986C/T—conflicting classifications of pathogenicity
rs76262543717:33,427,987C/A—conflicting classifications of pathogenicity
rs209152735217:33,427,988T/C—uncertain significance
rs121700136217:33,427,989G/A—uncertain significance
rs209152742817:33,427,990T/C—likely benign
rs214240873017:33,427,991A/T—uncertain significance
rs128103671017:33,427,992A/C—conflicting classifications of pathogenicity
rs78620329917:33,427,993T/C—likely benign
rs250912292417:33,427,999A/G—likely benign
rs76368307017:33,428,000C/A—uncertain significance
rs14766962717:33,428,002C/A—uncertain significance
rs79472698817:33,428,004G/Astop gaineduncertain significance
rs87665813117:33,428,005C/T—likely benign
rs159785537717:33,428,006T/C—uncertain significance
rs87665873717:33,428,007C/T—uncertain significance
rs214240891517:33,428,009G/A—uncertain significance
rs119510712517:33,428,011G/C—likely benign
rs14231640917:33,428,014C/T—likely benign
rs78620314417:33,428,015C/T—uncertain significance
rs78620234217:33,428,016C/G—uncertain significance
rs214240901117:33,428,017C/G—uncertain significance
rs214240902117:33,428,018C/T—pathogenic
rs58778187817:33,428,019A/G—uncertain significance
rs37431855317:33,428,020G/T—likely benign
rs75661671217:33,428,021G/C—conflicting classifications of pathogenicity
rs214240907617:33,428,023C/G—likely benign
rs159785543517:33,428,024C/A—uncertain significance
rs214240910217:33,428,025C/A—uncertain significance
rs88605281717:33,428,026A/C—uncertain significance
rs14530916817:33,428,027A/T—conflicting classifications of pathogenicity
rs75526551917:33,428,028T/C—conflicting classifications of pathogenicity
rs214240917817:33,428,029G/C—uncertain significance
rs88605281817:33,428,030T/G—uncertain significance
rs155556697917:33,428,034C/A—uncertain significance
rs155556698117:33,428,035C/T—likely benign
rs78620196117:33,428,037T/C—conflicting classifications of pathogenicity
rs105752337717:33,428,038C/T—likely benign
rs209152882317:33,428,039T/G—uncertain significance
rs11503154917:33,428,040C/T—conflicting classifications of pathogenicity
rs155556699017:33,428,041C/A—uncertain significance
rs74839893717:33,428,042T/C—uncertain significance
rs214240931217:33,428,043G/A—uncertain significance
rs131611445717:33,428,044G/C—conflicting classifications of pathogenicity
rs214240934117:33,428,047A/G—likely benign
rs20061528017:33,428,048C/T—uncertain significance
rs75939202917:33,428,049C/A—uncertain significance
rs214240937517:33,428,050T/C—uncertain significance
rs159785553817:33,428,051G/A—uncertain significance
rs78620344417:33,428,052T/C—uncertain significance
rs155556700317:33,428,054G/A—uncertain significance
rs159785556417:33,428,056C/T—uncertain significance
rs140378443417:33,428,057T/A—pathogenic
rs4547849117:33,428,058G/A—conflicting classifications of pathogenicity
rs214240946317:33,428,059G/C—likely benign
rs209152948917:33,428,060A/G—likely benign
rs209152955317:33,428,062G/T—likely benign
rs155556701217:33,428,064A/C—likely benign
rs214240952217:33,428,065G/A—likely benign
rs37444994317:33,428,066A/T—conflicting classifications of pathogenicity
rs96469617517:33,428,068G/T—conflicting classifications of pathogenicity
rs214240956917:33,428,069T/G—conflicting classifications of pathogenicity
rs214240957617:33,428,071A/C—likely benign
rs18181696017:33,428,072G/A—likely benign
rs209152973717:33,428,074A/C—likely benign
rs209152978317:33,428,075G/T—likely benign
rs991410917:33,428,159T/C—likely benign
rs4549609617:33,428,167A/G—likely benign
rs214241064117:33,428,201C/T—likely benign
rs214241066617:33,428,204C/A—likely benign
rs214241067317:33,428,205C/G—likely benign
rs214241068517:33,428,207G/A—likely benign
rs141786971317:33,428,208G/A—likely benign
rs132560546117:33,428,210G/A—likely benign
rs214241072917:33,428,211C/T—likely benign
rs214241073517:33,428,212T/G—likely benign
rs214241075617:33,428,214G/A—conflicting classifications of pathogenicity
rs159785574917:33,428,215C/T—likely benign
rs214241078817:33,428,217C/T—uncertain significance
rs214241081317:33,428,219C/T—conflicting classifications of pathogenicity
rs214241082117:33,428,220C/G—uncertain significance
rs214241084117:33,428,221T/C—uncertain significance
rs106050295917:33,428,222G/A—likely pathogenic

Showing 100 of 1,086 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.